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Table 2 Multivariate analysis including all antibody measures of immunity in the Chonyi cohort

From: Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

Antigen

Hazard ratio (95% CI)

Pvalue

RPI

0.20 (0.07 to 0.59)

0.003

Merozoite IgG1

2.16 (0.25 to 18.6)

0.482

Merozoite IgG3

0.79 (0.07 to 8.11)

0.844

MSP119

1.66 (0.42 to 6.53)

0.464

MSP2

0.15 (0.03 to 0.69)

0.015

MSP3

0.98 (0.30 to 3.14)

0.981

AMA1

0.62 (0.12 to 3.21)

0.578

EBA175

0.72 (0.15 to 3.51)

0.694

MSP1 block 2

0.55 (0.15 to 1.90)

0.345

  1. Hazard ratios comparing the risk of a clinical episode of malaria between children who had the top versus bottom tertile of antibody responses against each antigen. Chonyi cohort, n = 109. A similar analysis but including only variables that were significant in the univariate analysis (Table 1) did not alter these results and is presented in Additional file 1: Table S1. AMA1, apical membrane antigen 1; CI, confidence interval; EBA, erythrocyte binding antigen; MSP, merozoite surface protein; RPI, relative phagocytosis index.
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BMC Medicine

ISSN: 1741-7015

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