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Table 2 Multivariate analysis including all antibody measures of immunity in the Chonyi cohort

From: Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

Antigen Hazard ratio (95% CI) Pvalue
RPI 0.20 (0.07 to 0.59) 0.003
Merozoite IgG1 2.16 (0.25 to 18.6) 0.482
Merozoite IgG3 0.79 (0.07 to 8.11) 0.844
MSP119 1.66 (0.42 to 6.53) 0.464
MSP2 0.15 (0.03 to 0.69) 0.015
MSP3 0.98 (0.30 to 3.14) 0.981
AMA1 0.62 (0.12 to 3.21) 0.578
EBA175 0.72 (0.15 to 3.51) 0.694
MSP1 block 2 0.55 (0.15 to 1.90) 0.345
  1. Hazard ratios comparing the risk of a clinical episode of malaria between children who had the top versus bottom tertile of antibody responses against each antigen. Chonyi cohort, n = 109. A similar analysis but including only variables that were significant in the univariate analysis (TableĀ 1) did not alter these results and is presented in Additional file 1: Table S1. AMA1, apical membrane antigen 1; CI, confidence interval; EBA, erythrocyte binding antigen; MSP, merozoite surface protein; RPI, relative phagocytosis index.