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Table 3 Phagocytosis of merozoites is associated with a lower risk of multiple episodes of malaria in the low malaria transmission cohort

From: Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

Ngerenya children First episode Multiple episodes
  IRR (95% CI) P IRR (95% CI) P
Merozoite Phagocytosis     
Whole cohort (n = 287) 1.25(0.89 to 1.77) 0.186 1.17(0.61 to 2.24) 0.618
Recent exposurea (n = 81) 0.95(0.52 to 1.73) 0.888 0.34(0.13 to 0.85) 0.022
Recent exposureb (n = 40) 0.44(0.19 to 1.01) 0.055 0.13(0.03 to 0.46) 0.001
Merozoite ELISA     
Whole cohort (n = 287) 1.12(0.73 to 1.72) 0.582 1.18(0.58 to 2.40) 0.641
Recent exposurea (n = 81) 0.77(0.27 to 2.14) 0.618 0.54(0.09 to 3.12) 0.493
  1. Antibodies promoting phagocytosis of merozoites were fitted to age-adjusted multivariate regression models. Results are shown as incidence rate ratios (IRR), 95% confidence intervals (CIs) and P values. a,bChildren with documented exposure to malaria parasites in the preceding six and three months, respectively. Nearly all children with recent exposure (38/40) in the preceding three months were positive for anti-merozoite IgG by ELISA. Significant results at P < 0.05 are indicated in bold.