Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study

Table 3 Analyses of risk factors for ischemic stroke in patients with ovarian cancer

Predictive variables	Univariate analysis		Multivariate analysis^a
	HR (95% CI)	P	HR (95% CI)	P
Age ≥50	3.25 (2.49 to 4.25)	<0.001	2.21(1.64 to 2.99)	<0.001
Comorbidities
Diabetes mellitus	2.84 (2.19 to 3.67)	<0.001	1.71(1.27 to 2.29)	<0.001
Hypertension	3.15 (2.47 to 4.00)	<0.001	1.84(1.39 to 2.43)	<0.001
Chronic kidney disease	1.64 (1.12 to 2.39)	0.011	1.05(0.71 to 1.56)	0.791
Dyslipidemia	2.25 (1.75 to 2.89)	<0.001	1.09(0.81 to 1.46)	0.569
Coronary artery disease	3.66 (1.36 to 9.83)	0.010	2.01(0.74 to 5.42)	0.169
Atrial fibrillation	0.75 (0.11 to 5.31)	0.769
Peripheral arterial occlusive disease	3.09 (0.43 to 22.02)	0.261
Treatment ^b
Surgery^c	0.83 (0.64 to 1.06)	0.138
Chemotherapy	1.67 (1.25 to 2.25)	0.001	1.45(1.07 to 1.97)	0.017
Cisplatin-based	1.35 (1.06 to 1.73)	0.017	1.38(1.07 to 1.76)	0.012
Carboplatin-based	1.76 (1.37 to 2.25)	<0.001	1.46(1.13 to 1.89)	0.004
Non-platinum-based	1.24 (0.68 to 2.26)	0.490	1.12(0.61 to 2.04)	0.722

^aAll factors with P <0.1 in univariate analyses were included in the Cox multivariate analysis; ^btreatment was analyzed as a time-dependent covariate in the Cox regression model; ^csurgery included unilateral or bilateral salpingo-oophorectomy, or debulking surgery. CI, confidence interval; HR, hazard ratio.

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