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Table 1 Absorptive (apical to bisolateral) Michaelis–Menten constant (K m), carrier permeability (P c) and passive permeability (P m) for the transport of 20-(S)-camptothecin (CPT) across Caco-2 cells, MDCK II/wild type (wt) cells, MDCK II/P-glycoprotein (PGP) cells and MDCK II/Multidrug Resistance Protein 2 (MRP2) cells

From: Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

 

Apical to bisolateral

 

Caco-2

MDCK II/wt

MDCK II/PGP

MDCK II/MRP2

K m (μM)

70.1 ± 8.8

71.5 ± 9.7

69.7 ± 7.6

101.2 ± 17.8

P c (cm/s × 105)

8.3 ± 0.3

2.5 ± 0.7

2.2 ± 0.5

2.5 ± 0.4

P m (cm/s × 105)

0.43 ± 0.05a

Not determined

Not determined

Not determined

  1. Results reported as the mean ± standard deviation. a P m was estimated as the efflux P eff of CPT at 4°C.
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BMC Medicine

ISSN: 1741-7015

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