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Table 2 Distribution of MTHFR C677T genotypes in family-based migraine case and unrelated control groups.

From: The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura

 

Genotypes

 

Alleles

Group

C/C

C/T

T/T

N (genotypes)

C

T

Related-MO+MA

112 (35%)

167 (52%)

40 (13%)

319

391 (61%)

247 (39%)

Related MA*

84 (34%)

132 (53%)

31 (13%)

247

300 (61%)

194 (39%)

Unrelated Control

117 (43%)

129 (48%)

23 (9%)

269

363 (67%)

175 (33%)

  1. *genotype distribution comparison (Trend χ2 = 4.25, P = 0.039 adjusted for relatedness in affecteds), T/T genotype vs C/C (OR = 1.88, 95% CI: 1.01 – 3.52).