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Table 2 Distribution of MTHFR C677T genotypes in family-based migraine case and unrelated control groups.

From: The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura

  Genotypes   Alleles
Group C/C C/T T/T N (genotypes) C T
Related-MO+MA 112 (35%) 167 (52%) 40 (13%) 319 391 (61%) 247 (39%)
Related MA* 84 (34%) 132 (53%) 31 (13%) 247 300 (61%) 194 (39%)
Unrelated Control 117 (43%) 129 (48%) 23 (9%) 269 363 (67%) 175 (33%)
  1. *genotype distribution comparison (Trend χ2 = 4.25, P = 0.039 adjusted for relatedness in affecteds), T/T genotype vs C/C (OR = 1.88, 95% CI: 1.01 – 3.52).