Treatment Approach | Number of Trials | Reference Numbers | Summary of Results |
---|---|---|---|
Randomized Controlled Trials | Â | Â | Â |
Preoperative RT v. Surgery Alone | 6 | 5*,21–25†| Table 2 |
Postoperative RT v. Surgery Alone | 4 | 5*,27–29,47 | Table 3 |
Preoperative RT v. Postoperative RT | 1 | 5* | - |
Preoperative RT + Postoperative RT v. Postoperative RT | 1 | 30 | - |
Preoperative CT v. Surgery Alone | 6 | 24†,32–35‡,37,48 | Table 4 |
Preoperative + Postoperative CT v. Surgery Alone | 2 | 31,36 | Table 5 |
Postoperative CT v. Surgery Alone | 3 | 39–41‡ | Table 6 |
Preoperative CRT v. Surgery Alone | 6 | 24†,42–46,51–53‡ | Table 7 |
Postoperative CT v. Postoperative RT | 1 | 56 | - |
Preoperative CT v. Preoperative RT | 2 | 24†,57 | - |
Preoperative CRT v. Preoperative RT | 1 | 58 | - |
Postoperative Immunotherapy with RT or CRT v. RT or CRT | 1 | 59 | - |
Preoperative Hyperthermia with CRT v. preoperative CRT | 1 | 60 | - |
Meta-analyses | Â | Â | Â |
Preoperative RT v. Surgery Alone | 1 | 26 | - |
Preoperative CT v. Surgery Alone | 2 | 38,49,50 | - |
Preoperative CRT v. Surgery Alone | 2 | 54‡,55 | - |