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Table 1 Studies included in this systematic review.

From: Neoadjuvant or adjuvant therapy for resectable esophageal cancer: a systematic review and meta-analysis

Treatment Approach Number of Trials Reference Numbers Summary of Results
Randomized Controlled Trials    
Preoperative RT v. Surgery Alone 6 5*,21–25† Table 2
Postoperative RT v. Surgery Alone 4 5*,27–29,47 Table 3
Preoperative RT v. Postoperative RT 1 5* -
Preoperative RT + Postoperative RT v. Postoperative RT 1 30 -
Preoperative CT v. Surgery Alone 6 24†,32–35,37,48 Table 4
Preoperative + Postoperative CT v. Surgery Alone 2 31,36 Table 5
Postoperative CT v. Surgery Alone 3 39–41 Table 6
Preoperative CRT v. Surgery Alone 6 24†,42–46,51–53 Table 7
Postoperative CT v. Postoperative RT 1 56 -
Preoperative CT v. Preoperative RT 2 24†,57 -
Preoperative CRT v. Preoperative RT 1 58 -
Postoperative Immunotherapy with RT or CRT v. RT or CRT 1 59 -
Preoperative Hyperthermia with CRT v. preoperative CRT 1 60 -
Meta-analyses    
Preoperative RT v. Surgery Alone 1 26 -
Preoperative CT v. Surgery Alone 2 38,49,50 -
Preoperative CRT v. Surgery Alone 2 54,55 -
  1. Note: CT indicates chemotherapy; CRT, chemoradiation; RT, radiotherapy; v., versus.
  2. * The four-arm trial by Fok et al [5] contributed to three comparisons.
  3. † The four-arm trial by Nygaard et al [24] contributed to four comparisons.
  4. ‡ Reports published in abstract form only [35,41,51,53,54].