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Table 1 Included studies.

From: Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials

   METHODS PARTICIPANTS INTERVENTIONS OUTCOMES
INCLUDED STUDIES (date of publication) Randomised Double-blind Three+ arm study Duration (weeks) Only Schizophrenia History Total number of participants Age (years) Sex CPZ dose (mg/day) Number allocated CPZ Number allocated placebo Leaving the study early Global improvement Mental State Side-effects Global clinical state Behaviour Relapse
1955 Hall   9 C 175 20–59 M+F 750 max 87 88      
  Vaughan   U/K   C 48 M = 43 F 75–450 24 24        
1956 Shepherd U/K 6 C 24 27–52 F 300 8 8      
1958 Abrams    4 C 40 20–55 F 200–600 20 20       
  Grygier U/K   24 C 30 m = 50 F 150 15 15        
  Hine   20 C 22 30–50 F 750 max 11 11      
  Simon   4   U/K 80 m = 31 U/K 200–1200 20 0       
1959 Baker 5   C 25 33–79 F 150–300 7 7    
  Flemming 26 C 63 m = 58 F 75–300 21 21       
  Walsh U/K 8 C 66 27–50 F 75–300 22 22        
1960 Englhardt 78 U/K 173 18–40 U/K 50–800 62 56      
  Hamilton 8 C 54 m = 38 M 300 18 18       
  Payne 6 C 21 23–73 M 25–100 7 7        
  Somerville 6   C+A 60 24–58 F 200–800 15 30      
1961 Clark 24 C 60 26–52 F 200–800 20 20        
  Lorr 12   A 308 <50 M 50–100 63 61       
  Kurland 6   A 277 18–61 M+F 300 33 72      
  Schiele 16 C 80 m = 80 M 200–1000 20 20     
  Smith 14 C 30 m = 42 M+F 150–600 13 15        
1963 Bishop 10 C 30 U/N M+F 800 10 10      
  Fink U/K 6   S 311 m = 31 M+F 1200 51 44       
1964 NIMH 6 A 463 16–45 M+F 200–1600 112 125       
1966 Reardon 4 A 34 U/K M+F 300–600 11 12      
  Saretsky   12 A 40 <55 M 400 20 20       
1967 Clark   10 C 72 25–55 F 678 m 51 21       
  Letemendia   39   C 28 <65 M 300 14 14       
1968 Clark a 14 C 72 20–60 F 1000 max 18 36      
  Clark b 16 C 69 20–60 F 1000 max 23 23       
  Cohen 60 C 126 18–42 M+F 180 42 42       
  Prien 24 C 838 19–55 M+F 2000 208 212    
            300 208         
1969 Tetreault 12 C 45 m = 50 F 300–600 15 15      
1970 Clark a 12 C 44 22–55 M+F 200–1000 15 14    
  Clark b   24 C 71 21–60 F 150–600 54 18       
1971 Clark 4 C 86 21–45 M+F 200–1000 23 21      
1972 Clark 12 C 55 21–60 M+F 1000 19 18     
  Serafetinedes 12 C 57 21–61 M+F 1000 max 14 13      
1973 Hogarty   156 S 374 18–53 M+F 270 m 192 182      
  Klein   6   88 17–61 M+F 300–1200 46 42       
1974 Reschke 0.1 A 50 19–57 M+F 25 im 10 11      
1975 Ban 12 C+A 30 17–46 M+F 200–800 10 10      
  Hamill    0.7 A 44 18–55 M+F 306–475 22 22       
1977 Clark 12 C 27 23–61 M+F 1000 9 9      
  Spohn   6+ U/K 40 18–55 M+F 200 min 20 20       
1978 Rappaport    U/K A 127 16–40 M 300–900 53 74      
1981 Peet 12 U/K 53 m = 51 M+F 400 max 16 18      
1982 Nishikawa 156 S 55 m = 33 M+F 75 10 10       
1986 Zuoze   4 C 60 m = 36 U/K 450 m 20 20        
1990 Chouinard 4 A 62 19–62 M+F 300–1200 21 21      
1991 Borison 4 A 30 22–58 M 400–1600 9 10        
2000 Cooper 8 C 159 18–42 M+F 600 53 53     
  1. Key: = Yes; U/K = Unknown; C = Chronic; A = Acute; M = Male; F = Female; m = Mean; im = Intramuscular injection.