Skip to main content

Table 2 Effect of simvastatin allocation on vascular and non-vascular causes of death

From: The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393]

Cause of death Simvastatin-allocated (10,269) Placebo- allocated (10,267) Death rate ratio (& 95% CI) P-value
Coronary     
   Acute MI 141 (1.4%) 191 (1.9%) 0.73 (0.59 – 0.91)  
   Sudden death 147 (1.4%) 154 (1.5%) 0.95 (0.75 – 1.19)  
   Heart failure* 65 (0.6%) 78 (0.8%) 0.82 (0.59 – 1.15)  
   Other coronary 234 (2.3%) 284 (2.8%) 0.82 (0.69 – 0.97)  
   Subtotal: Coronary 587 (5.7%) 707 (6.9%) 0.82 (0.74 – 0.92) 0.0005
Stroke     
   Haemorrhagic 23 (0.2%) 24 (0.2%) 0.95 (0.54 – 1.68)  
   Ischaemic (or unknown) 73 (0.7%) 95 (0.9%) 0.76 (0.56 – 1.03)  
   Subtotal: Stroke 96 (0.9%) 119 (1.2%) 0.80 (0.61 – 1.05) 0.1
Other vascular     
   Peripheral vascular 58 (0.6%) 63 (0.6%) 0.91 (0.64 – 1.30)  
   Other cardiac* 40 (0.4%) 48 (0.5%) 0.83 (0.54 – 1.25)  
   Subtotal: Other vascular 98 (1.0%) 111 (1.1%) 0.88 (0.67 – 1.15) 0.3
VASCULAR 781 (7.6%) 937 (9.1%) 0.83 (0.75 – 0.91) <0.0001
Neoplastic     
   Respiratory 127 (1.2%) 133 (1.3%) 0.94 (0.74 – 1.20)  
   Gastrointestinal 112 (1.1%) 103 (1.0%) 1.08 (0.82 – 1.41)  
   Genitourinary 47 (0.5%) 46 (0.4%) 1.01 (0.67 – 1.52)  
   All others 73 (0.7%) 62 (0.6%) 1.17 (0.83 – 1.63)  
   Subtotal: Neoplastic 359 (3.5%) 345 (3.4%) 1.03 (0.89 – 1.19) 0.7
Other non-vascular     
   Respiratory 90 (0.9%) 114 (1.1%) 0.78 (0.59 – 1.03)  
   Gastrointestinal 35 (0.3%) 41 (0.4%) 0.85 (0.54 – 1.33)  
   Other medical 47 (0.5%) 49 (0.5%) 0.95 (0.64 – 1.42)  
   Non-medical 16 (0.2%) 21 (0.2%) 0.75 (0.40 – 1.44)  
NON-VASCULAR 547 (5.3%) 570 (5.6%) 0.95 (0.85 – 1.07) 0.4
ALL DEATHS 1328 (12.9%) 1507 (14.7%) 0.87 (0.81 – 0.94) 0.0003
  1. * Heart failure deaths were subdivided into those considered to be due to coronary disease and those (5 versus 8) due to other vascular (or unknown) causes.
  2. † Includes renal, infectious, metabolic, neurological and unknown deaths.