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Table 3 Effect of influenza vaccination on respiratory tract infections (RTIs) in general, with influenza positive swabs and/or 4-fold titre rise: multivariate regression analysis for correlated data (GEE)

From: The effect of giving influenza vaccination to general practitioners: a controlled trial [NCT00221676]

Outcome RTI in general (n = 202) RTI with positive swabs for influenza (n = 202) RTI with pos swabs and/or 4-fold titre rise for influenza (n = 150)
Parameter1 OR estimate 95%CI   OR estimate 95%CI   OR estimate 95%CI  
   Lower limit Upper limit   Lower limit Upper limit   Lower limit Upper limit
Vaccine†2 when GP is 30 years old 0.35 0.13 0.96 0.1 0.01 0.75 0.13 0.02 0.98
Vaccine† when GP is 50 years old 1.79 0.80 4.00 1.41 0.35 5.76 0.82 0.21 3.25
Co-variates          
Year 2002/2003 0.98 0.49 1.96 0.42 0.13 1.42 0.52 0.18 1.53
Age‡3 0.49 0.17 1.43 0.58 0.17 1.96 0.37 0.09 1.53
Gender† 0.60 0.33 1.10 0.96 0.29 3.23 0.99 0.33 2.94
Basic immunity (natural logarithm of titre1)‡4 1.18 0.91 1.55 0.57 0.37 0.89 0.57 0.38 0.86
Mean number of patient contacts/day‡5 1.17 0.50 2.76 1.77 0.47 6.69 3.13 0.69 14.11
Mean number of contacts with influenza patients/day‡6 0.67 0.44 1.00 0.33 0.10 1.12 0.39 0.13 1.16
Family members with influenza† 1.88 0.97 3.64 9.24 2.91 29.40 3.62 1.20 10.89
Colleagues with influenza† 1.10 0.60 2.01 0.60 0.19 1.84 0.71 0.25 2.04
Having young children < 7 years of age† 2.00 0.95 4.24 1.37 0.42 4.52 1.04 0.30 3.67
Working in Child and family preventive medicine facility† 0.76 0.31 1.87 1.76 0.52 5.92 1.15 0.28 4.66
† dichotomous yes(1), no(0)          
‡ continuous          
1Intercept = 0.96 -1.63 3.54 0.68 -2.24 3.61 2.44 -1.41 6.28
2 Crude OR vaccine = 0.97 0.56 1.67 0.55 0.24 1.28 0.35 0.15 0.79
3 OR for difference of 20 years          
4 OR for a difference of 1 in natural logarithm of titre1          
5 OR for a difference of 20 patients          
6 OR for a difference of 2 influenza patients