Hyper-IgG4 disease: report and characterisation of a new disease

Table 4 Histopathology

Patient no., sex, age	Organ	Fibrosis*	Lymphoplasmacytic infiltrate†	Lymphoid follicles	Venulitis	Eosinophilic component	IgG4-positive plasma cells‡
(1) Male, 52	Kidney	+++	+++	Yes	No	No	3
	Liver	++	+	No	No	Yes	0
(2) Male, 73	Retroperitoneum	+++	+++	Yes	Yes	Yes	3
(3) Male, 39	Omentum	+	++	Yes	No	No	3
(4) Male, 53	Retroperitoneum	+++	+++	Yes	Yes	Yes	3
(5) Male, 45	Periureter	+++	+++	Yes	Yes	No	2
(6) Female, 58	Retroperitoneum	+++	+++	No	Yes	No	3
(7) Female, 55	Para-aortic tissue	+++	+++	Yes	Yes	No	3
(8) Male, 47	Periureter tissue	+++	+	Yes	Yes	No	2
(9) Male, 48	Retroperitoneum	+++	++	No	No	No	2
(10) Male, 73	Retroperitoneum	+++	+++	Yes	Yes	Yes	1
(11) Female, 56	Retroperitoneum	+++	++	Yes	No	No	1
(12) Male, 53	Liver	++	+	No	No	No	1
	Colon	++	+	No	No	No	0

*Degree of interstitial fibrosis: +, mild; ++, moderate; +++, severe fibrosis.
†Degree of inflammation: +++ (severe), >100 inflammatory cells/HPF; ++ (moderate), 30–100 cells/HPF; + (mild), 10–30 cells/HPF
‡IgG4-positive plasma cells: 0, no IgG4 plasma cells/high power field (HPF); 1, ≤ 20 cells/HPF), 2, 20–50 cells/HPF; 3, ≥ 50 cells/HPF (criteria of Aoki et al [12]).

ISSN: 1741-7015