Skip to main content

Table 2 Comparison of HLA-A and B carrier frequencies between stage IV melanoma patients and healthy bone marrow donors. HLA-A and -B carrier frequencies of stage IV melanoma patients (739 HLA-A; 709 HLA-B) and healthy bone marrow donors (13,386) were compared using a two sided chi-square test with a 95% confidence interval and sorted according to the absolute difference. Results are regarded as significant for p values < 0.01; alleles with significant changes are depicted in bold; results are sorted according to the percentage difference. Only alleles with carrier frequencies > 5% are included. Subtypes are only included if more than 89% of the corresponding allele was subtyped in the melanoma and bone marrow donor group. OR: odds ratio; ci: confidence interval.

From: HLA-B8 association with late-stage melanoma – an immunological lesson?

B8 16.22% 20.33% 4.12% 0.0079 * 0.76 0.6184 to 0.9302
HLA melanoma control difference p sign. OR 95% ci OR
B35 15.23% 18.53% 3.29% 0.0273 ns 0.79 0.6409 to 0.9744
B7 27.79% 25.34% 2.45% 0.1452 ns 1.13 0.9575 to 1.342
A9 23.68% 21.42% 2.26% 0.1452 ns 1.14 0.9561 to 1.356
A10 11.23% 13.33% 2.1% 0.1015 ns 0.82 0.6509 to 1.039
A26 5.01% 6.98% 1.97% 0.0393 ns 0.70 0.5015 to 0.9846
B40 11.99% 13.84% 1.85% 0.1624 ns 0.85 0.6728 to 1.070
B60 8.46% 10.32% 1.85% 0.1123 ns 0.80 0.6133 to 1.053
B15 14.1% 15.8% 1.7% 0.2266 ns 0.88 0.7047 to 1.087
A28 6.63% 8.3% 1.67% 0.1076 ns 0.78 0.5834 to 1.055
B16 9.59% 7.94% 1.65% 0.1151 ns 1.23 0.9504 to 1.591
B13 5.64% 6.96% 1.31% 0.1762 ns 0.80 0.5774 to 1.108
A32 5.55% 6.69% 1.14% 0.2232 ns 0.82 0.5939 to 1.132
B12 24.96% 23.83% 1.13% 0.4902 ns 1.06 0.8930 to 1.266
A11 9.34% 10.46% 1.12% 0.3308 ns 0.88 0.6839 to 1.137
A24 18.13% 17.26% 0.88% 0.5401 ns 1.06 0.8761 to 1.287
A3 28.96% 28.1% 0.85% 0.6122 ns 1.04 0.8856 to 1.228
B18 10.58% 9.79% 0.79% 0.4900 ns 1.09 0.8526 to 1.395
A19 22.46% 21.79% 0.67% 0.6671 ns 1.04 0.8705 to 1.242
B44 23.41% 22.78% 0.63% 0.6942 ns 1.04 0.8666 to 1.238
A2 51.42% 51.13% 0.29% 0.8768 ns 1.01 0.8724 to 1.173
A1 28.69% 28.94% 0.25% 0.8825 ns 0.99 0.8385 to 1.163
B51 10.3% 10.54% 0.24% 0.8361 ns 0.97 0.7598 to 1.249
B27 8.89% 8.73% 0.15% 0.8884 ns 1.02 0.7814 to 1.329
A25 5.55% 5.61% 0.06% 0.9429 ns 0.99 0.7151 to 1.366