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Table 1 Summary of diaphragm muscle parameters from experiment 1. Effect of 3 months of treatment with either vehicle, 1 mg/kg prednisone, 30 ug/kg PG873637 or the combination of prednisone plus PG873637 on male 3-month-old (at time 0) mdx mice.

From: Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice

  Time 0 Vehicle Prednisone PG-873637 PG-873637 + prednisone
Number of animals 10 10 10 9 8
Initial body mass (g) 28.49 (0.47) 28.53 (0.74) 28.36 (0.77) 28.39 (0.60) 27.37 (0.75)
Final body mass (g) 28.49 (0.47) 31.36† (0.90) 29.83† (0.62) 34.56† (0.38) 32.09† (0.48)
Diaphragm mass (g) 0.0031 (0.0002) 0.0035 (0.0003) 0.0038† (0.0002) 0.0041† (0.0003) 0.0038† (0.0003)
Diaphragm sPo (kN/m2) 96.478 (9.441) 74.100† (6.171) 90.340 (7.126) 95.811* (7.389) 116.91* (4.067)
Diaphragm Po (mN) 42.133 (3.239) 37.467 (4.043) 46.270 (2.720) 49.844* (3.557) 56.838*† (4.075)
Diaphragm Pt (mN) 11.511 (1.148) 9.778 (1.474) 12.470 (0.776) 10.278 (1.031) 12.063 (1.058)
Diaphragm HRT (ms) 56.289 (2.195) 50.222 (6.179) 51.070 (4.049) 50.089 (3.987) 45.875† (2.344)
Diaphragm TPT (ms) 33.511 (0.870) 33.989 (1.814) 33.650 (0.949) 31.267 (1.650) 29.588*† (0.685)
Diaphragm myofiber CSA 1634.2 (56.89) 1158.4† (55.55) 1429.5* (91.73) 1375.7*† (59.17) 1366.0*† (36.45)
  1. sPo, muscle specific force; Po, muscle absolute force; Pt, muscle peak twitch force; HRT, muscle half relaxation time; TPT, muscle time to peak tension; CSA, myofiber cross-sectional area. All data are given as the mean with standard error of the mean in parenthesis. *Statistically significant difference (p < 0.05) versus the appropriate vehicle control; †statistically significant difference (p < 0.05) versus time 0.