| Time 0 | Vehicle | Prednisone | PG-873637 | PG-873637 + prednisone |
---|---|---|---|---|---|
Number of animals | 10 | 10 | 10 | 9 | 8 |
Initial body mass (g) | 28.49 (0.47) | 28.53 (0.74) | 28.36 (0.77) | 28.39 (0.60) | 27.37 (0.75) |
Final body mass (g) | 28.49 (0.47) | 31.36†(0.90) | 29.83†(0.62) | 34.56†(0.38) | 32.09†(0.48) |
Diaphragm mass (g) | 0.0031 (0.0002) | 0.0035 (0.0003) | 0.0038†(0.0002) | 0.0041†(0.0003) | 0.0038†(0.0003) |
Diaphragm sPo (kN/m2) | 96.478 (9.441) | 74.100†(6.171) | 90.340 (7.126) | 95.811* (7.389) | 116.91* (4.067) |
Diaphragm Po (mN) | 42.133 (3.239) | 37.467 (4.043) | 46.270 (2.720) | 49.844* (3.557) | 56.838*†(4.075) |
Diaphragm Pt (mN) | 11.511 (1.148) | 9.778 (1.474) | 12.470 (0.776) | 10.278 (1.031) | 12.063 (1.058) |
Diaphragm HRT (ms) | 56.289 (2.195) | 50.222 (6.179) | 51.070 (4.049) | 50.089 (3.987) | 45.875†(2.344) |
Diaphragm TPT (ms) | 33.511 (0.870) | 33.989 (1.814) | 33.650 (0.949) | 31.267 (1.650) | 29.588*†(0.685) |
Diaphragm myofiber CSA | 1634.2 (56.89) | 1158.4†(55.55) | 1429.5* (91.73) | 1375.7*†(59.17) | 1366.0*†(36.45) |