| Time 0 | Vehicle | Prednisone | PG-873637 | PG-873637 + prednisone |
---|
Number of animals | 10 | 10 | 10 | 9 | 8 |
Fibrosis | 2.0 (0) | 3.6†(0.16) | 3.2†(0.25) | 2.6*†(0.29) | 1.9*‡ (0.13) |
Inflammation | 1.7 (0.26) | 1.7 (0.15) | 1.4 (0.16) | 1.3* (0.15) | 1.2* (0.15) |
- Diaphragm muscle samples were evaluated as described in Methods. All data are given as the mean with standard error of the mean in parenthesis. *Statistically significant difference (p < 0.05) versus the appropriate vehicle control; †statistically significant difference (p < 0.05) versus time 0; ‡ statistically significant difference (p < 0.05) versus PG-873637.