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Table 2 Summary of histopathology analysis for fibrosis and inflammation in H&E and Masson's trichrome stained diaphragm muscle from mdx mice in experiment 1. Effect of 3 months of treatment with either vehicle, 1 mg/kg prednisone, 30 ug/kg PG-873637 or the combination of prednisone plus PG-873637 on male 3-month-old (at time 0) mdx mice.

From: Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice

  Time 0 Vehicle Prednisone PG-873637 PG-873637 + prednisone
Number of animals 10 10 10 9 8
Fibrosis 2.0 (0) 3.6† (0.16) 3.2† (0.25) 2.6*† (0.29) 1.9*‡ (0.13)
Inflammation 1.7 (0.26) 1.7 (0.15) 1.4 (0.16) 1.3* (0.15) 1.2* (0.15)
  1. Diaphragm muscle samples were evaluated as described in Methods. All data are given as the mean with standard error of the mean in parenthesis. *Statistically significant difference (p < 0.05) versus the appropriate vehicle control; † statistically significant difference (p < 0.05) versus time 0; ‡ statistically significant difference (p < 0.05) versus PG-873637.