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Table 2 Summary of histopathology analysis for fibrosis and inflammation in H&E and Masson's trichrome stained diaphragm muscle from mdx mice in experiment 1. Effect of 3 months of treatment with either vehicle, 1 mg/kg prednisone, 30 ug/kg PG-873637 or the combination of prednisone plus PG-873637 on male 3-month-old (at time 0) mdx mice.

From: Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice

 

Time 0

Vehicle

Prednisone

PG-873637

PG-873637 + prednisone

Number of animals

10

10

10

9

8

Fibrosis

2.0 (0)

3.6† (0.16)

3.2† (0.25)

2.6*† (0.29)

1.9*‡ (0.13)

Inflammation

1.7 (0.26)

1.7 (0.15)

1.4 (0.16)

1.3* (0.15)

1.2* (0.15)

  1. Diaphragm muscle samples were evaluated as described in Methods. All data are given as the mean with standard error of the mean in parenthesis. *Statistically significant difference (p < 0.05) versus the appropriate vehicle control; † statistically significant difference (p < 0.05) versus time 0; ‡ statistically significant difference (p < 0.05) versus PG-873637.