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Table 2 Models used for analysis of the effects of statins on incidence of dementia using the Cox proportional survival method.

From: Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

  Model 1 Model 2 Model 3
Variable HR p value 95% Confidence limits for HR HR p value 95% Confidence limits for HR HR p value 95% Confidence limits for HR
Atorvastatin             
   Versus CV 0.80 0.0005 0.71 0.91 0.90 0.09 0.79 1.02 0.91 0.11 0.80 1.02
   Age      1.11 <0.0001 1.10 1.12 1.11 <0.0001 1.10 1.11
   Hypertension      1.10 0.0590 1.00 1.20     
   CVD      1.13 0.0005 1.05 1.20     
   Diabetes      1.12 0.0009 1.05 1.20     
   Charlson Index          1.78 <0.0001 1.66 1.91
Lovastatin             
   Versus CV 0.98 0.70 0.89 1.08 0.95 0.32 0.86 1.05 0.95 0.34 0.86 1.05
   Age      1.11 <0.0001 1.10 1.12 1.11 <0.0001 1.10 1.11
   Hypertension      1.09 0.07 0.99 1.19     
   CVD      1.12 0.0005 1.05 1.20     
   Diabetes      1.12 0.0009 1.05 1.20     
   Charlson Index          1.74 <0.0001 1.62 1.86
Simvastatin             
   Versus CV 0.45 <0.0001 0.43 0.47 0.45 <0.0001 0.43 0.48 0.46 <0.0001 0.44 0.48
   Age      1.11 <0.0001 1.10 1.11 1.11 <0.0001 1.10 1.11
   Hypertension      1.07 0.07 1.00 1.15     
   CVD      1.09 0.0012 1.04 1.15     
   Diabetes      1.08 0.0034 1.03 1.14     
   Charlson Index          1.72 <0.0001 1.63 1.81
  1. HR, hazard ratio, CVD, cardiovacular disease, CV, cardiovascular.
  2. Model 1 included an adjustment for the interaction between dementia and age; model 2 included adjustments for the interaction between dementia and three disorders associated with increased risk of dementia.; model 3 included adjustments for the interaction between dementia and the Charlson Index, which is an index that provides a broad assessment for the amount of chronic disease. For the purpose of analysis of interactions with the Charlson Index, subjects with a Charlson Index of 0 or 1 were compared with those with a Charlson Index of ≥2.
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BMC Medicine

ISSN: 1741-7015

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