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Table 3 Interactions selected by MDR with permutation P-value less than 5%

From: Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario

Rank Interactions Testing accuracy* Permutation P-value
1 IL1A-[Ala114Ser]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
58.2% <0.001
2 ESR1-[Ser10Ser]
CYP17-[C(518)T]
IL10-[G(-1082)A]
COMT-[Met108/158Val]
PTEN- [(IVS4+109)ins/del5]
CCND1-[Pro241Pro]
60.2% <0.001
3 CYP17-[C(518)T]
BARD1-[Pro24Ser]
COMT-[Met108/158Val]
MMP1-[1G(-1607)2G]
CCND1-[Pro241Pro]
58.4% 0.001
4 IL13-[Arg130Gln]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
57.5% 0.002
5 CYP17-[C(518)T]
XPD-[Lys751Gln]
GSTP1-[Ile105Val]
GADD45-[C(IVS3+168)T]
56.7% 0.006
6 XPD-[Lys751Gln]
IL10-[G(-1082)A]
GSTP1-[Ile105Val]
COMT-[Met108/158Val]
MMP1-[1G(-1607)2G]
CCND1-[Pro241Pro]
57.5% 0.006
7 ESR1-[Ser10Ser]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
MMP1-[1G(-1607)2G]
PTEN-[(IVS4+109)ins/del5
57.2% 0.007
8 CYP17-[C(518)T]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
MTHFR-[Ala222Val]
COMT-[Met108/158Val]
CCND1-[Pro241Pro]
58.2% 0.007
9 XPD-[Lys751Gln]
IL10-[G(-1082)A]
55.9% 0.009
10 CYP17-[C(518)T]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
MTHFR-[Ala222Val]
COMT-[Met108/158Val]
56.3% 0.016
11 BARD1-[Pro24Ser]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
55.6% 0.017
12 ESR1-[Ser10Ser]
XPD-[Lys751Gln]
MMP1-[1G(-1607)2G]
PTEN-[(IVS4+109)ins/del5
55.9% 0.017
13 COMT-[Met108/158Val]
CCND1-[Pro241Pro]
55.2% 0.019
14 CYP17-[C(518)T]
IL10-[G(-1082)A]
COMT-[Met108/158Val]
PTEN-[(IVS4+109)ins/del5]
CCND1-[Pro241Pro]
55.7% 0.020
15 IL10-[G(-1082)A]
MTHFR-[Ala222Val]
GSTP1-[Ile105Val]
COMT-[Met108/158Val]
55.7% 0.023
16 IL13-[Arg130Gln]
CYP17-[C(518)T]
54.5% 0.037
17 BARD1-[Pro24Ser]
XPD-[Lys751Gln]
54.7% 0.037
18 CYP17-[C(518)T]
XPD-[Lys751Gln]
IL10-[G(-1082)A]
COMT-[Met108/158Val]
PTEN- [(IVS4+109)ins/del5]
CCND1-[Pro241Pro]
55.9% 0.046
  1. *1 - prediction error.