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Figure 5 | BMC Medicine

Figure 5

From: Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium

Figure 5

Patterns of co-growth of 4T1-GFP breast cancer cells (in green) and pulmonary microvascular endothelial cells (DIC channel, gray) in vitro. Co-culture of wild-type 4T1-GFP cells (4T1), Cx43-C61S mutation expressing 4T1-GFP cells (C61S), and connexin-43 overexpressing cells (Cx43OE), and pulmonary microvascular endothelial cells exhibited side-by-side growth and shared borders. In contrast, 4T1-GFP cells expressing the mutant Cx43-G138R (G138R) grew on top of endothelial cells without integration into the monolayer.

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BMC Medicine

ISSN: 1741-7015

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