Table 2 Distribution of valvular regurgitation at initial echocardiogram in 918 men exposed to fenfluramine and/or dexfenfluramine
From: Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals
| Â | Ages | |||||||
|---|---|---|---|---|---|---|---|---|
|  | <20 (n = 12) | 20–29 (n = 31) | 30–39 (n = 125) | 40–49 (n = 249) | 50–59 (n = 281) | 60–69 (n = 166) | 70+ (n = 54) | All ages (n = 918) |
Aortic regurgitation | Â | Â | Â | Â | Â | Â | Â | Â |
   None (%) | 91.7 | 90.3 | 86.4 | 79.5 | 73.7 | 62.0 | 55.6 | 74.6 |
   Trace (%) | 8.3 | 9.7 | 10.4 | 13.6 | 12.8 | 24.1 | 27.8 | 15.5 |
   Mild (%) | 0 | 0 | 2.4 | 4.8 | 12.1 | 8.4 | 13.0 | 7.6 |
   moderate (%) | 0 | 0 | 0.80 | 2.0 | 1.4 | 4.2 | 3.7 | 2.1 |
   severe (%) | 0 | 0 | 0 | 0 | 0 | 1.2 | 0 | 0.22 |
Mitral regurgitation | Â | Â | Â | Â | Â | Â | Â | Â |
   none (%) | 58.3 | 58.1 | 48.0 | 44.2 | 35.9 | 34.9 | 44.4 | 41.2 |
   trace (%) | 33.3 | 35.5 | 48.0 | 48.6 | 54.4 | 47.6 | 46.3 | 49.4 |
   Mild (%) | 8.3 | 3.2 | 4.0 | 7.2 | 7.5 | 9.6 | 5.6 | 7.1 |
   moderate (%) | 0 | 0 | 0 | 0 | 1.1 | 6.0 | 3.7 | 1.6 |
   severe (%) | 0 | 3.2 | 0 | 0 | 1.1 | 1.8 | 0 | 0.76 |
Tricuspid regurgitation | Â | Â | Â | Â | Â | Â | Â | Â |
   none (%) | 41.7 | 38.7 | 37.6 | 34.1 | 31.7 | 26.5 | 31.5 | 32.5 |
   trace (%) | 33.3 | 51.6 | 60.0 | 56.6 | 62.6 | 59.6 | 55.6 | 59.0 |
   Mild (%) | 16.7 | 9.7 | 2.4 | 7.2 | 4.3 | 9.0 | 9.3 | 6.3 |
   moderate (%) | 0 | 0 | 0 | 2.0 | 0.71 | 4.2 | 3.7 | 1.7 |
   severe (%) | 8.3 | 0 | 0 | 0 | 0.71 | 0.60 | 0 | 0.44 |