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Table 2 Distribution of valvular regurgitation at initial echocardiogram in 918 men exposed to fenfluramine and/or dexfenfluramine

From: Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals

  Ages
  <20 (n = 12) 20–29 (n = 31) 30–39 (n = 125) 40–49 (n = 249) 50–59 (n = 281) 60–69 (n = 166) 70+ (n = 54) All ages (n = 918)
Aortic regurgitation         
   None (%) 91.7 90.3 86.4 79.5 73.7 62.0 55.6 74.6
   Trace (%) 8.3 9.7 10.4 13.6 12.8 24.1 27.8 15.5
   Mild (%) 0 0 2.4 4.8 12.1 8.4 13.0 7.6
   moderate (%) 0 0 0.80 2.0 1.4 4.2 3.7 2.1
   severe (%) 0 0 0 0 0 1.2 0 0.22
Mitral regurgitation         
   none (%) 58.3 58.1 48.0 44.2 35.9 34.9 44.4 41.2
   trace (%) 33.3 35.5 48.0 48.6 54.4 47.6 46.3 49.4
   Mild (%) 8.3 3.2 4.0 7.2 7.5 9.6 5.6 7.1
   moderate (%) 0 0 0 0 1.1 6.0 3.7 1.6
   severe (%) 0 3.2 0 0 1.1 1.8 0 0.76
Tricuspid regurgitation         
   none (%) 41.7 38.7 37.6 34.1 31.7 26.5 31.5 32.5
   trace (%) 33.3 51.6 60.0 56.6 62.6 59.6 55.6 59.0
   Mild (%) 16.7 9.7 2.4 7.2 4.3 9.0 9.3 6.3
   moderate (%) 0 0 0 2.0 0.71 4.2 3.7 1.7
   severe (%) 8.3 0 0 0 0.71 0.60 0 0.44
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