Skip to main content

Table 2 Selected estimates for screening test accuracy, costs and utilities.

From: Human papillomavirus testing with Pap triage for cervical cancer prevention in Canada: a cost-effectiveness analysis

Screening Adherence (1)

<20

0.5-0.75 (0.35-1.0)

  

20-29

0.5-0.8 (0.35-1.0)

  

30-39

0.7-0.9 (0.5-1.0)

  

40-49

0.6-0.9 (0.4-1.0)

  

50+

0.3-1.0 (0.2-1.0)

  

Screening Test Accuracy [8, 21]1,2

 

Age <30

Age 30+

 

Pap sensitivity for CIN 1+

0.42 (0.31-0.72)

0.32 (0.30-0.66)

 

Pap specificity for <CIN 1

0.98 (0.80-0.95)

0.94 (0.82-0.95)

 

HPV sensitivity for CIN 1+

0.83 (0.68-1.0)

0.71 (0.65-1.0)

 

HPV specificity for <CIN 1

0.83 (0.80-0.97)

0.97 (0.94-1.0)

 

HPV and Pap sensitivity for CIN 1+

0.88 (0.72-1.0)

0.75 (0.69-1.0)

 

HPV and Pap specificity for <CIN 1

0.82 (0.79-0.96)

0.95 (0.92-1.0)

 

Costs in Canadian $ (2006)[26–29, 31]3

 

Canada and Ontario

Alberta

Newfoundland

Conventional Pap

$28 ($14-$56)

$30 ($15-$59)

$29 ($14-$58)

Liquid-based Pap

$32 ($16-64)

$35($17-$70)

$33 ($16-$65)

HPV test (hc2)

$53 ($14-$106)

$50 ($14-$100)

$53 ($14-$106)

Colposcopy + biopsy

$337 ($168-$673)

$376 ($188-$752)

$412 ($206-$824)

LEEP

$965 ($83-$1930)

$1082 ($541-$2164)

$1044 ($522-$2088)

Stage I Cancer

$11153 ($5576-$22305)

$12126 ($6063-$24253)

$11898 ($5949-$23797)

Stage II - III Cancer

$17644 ($8822-$35288)

$19185 ($9592-$38369)

$18824 ($9412-$37648)

Stage IV - Cancer

$24110 ($12055-$48220)

$26215 ($13107-$52430)

$25722 ($21861-$51445)

Utilities[32]4

False-positive screening test result

-.02

Duration

2 1/2 months[8]

Stage I Cancer

0.76

Duration

5 years 5

Stage II - IV Cancer

0.67

Duration

5 years 5

  1. 1 Ranges used for beta distributions for probabilistic sensitivity analyses
  2. 2 Estimates of sensitivity assumed to be the same for LBC; specificity estimated to be 0.84[23] of base estimate of specificity for conventional Pap.
  3. 3 Ranges used for normal distributions for costs for probabilistic sensitivity analyses
  4. 4 Cost per quality-adjusted life-year calculated in sensitivity analyses
  5. 5 Women who are alive at the end of 5 years are assumed to enter the cancer survivor state. The utility for a cancer survivor is assumed to be 1.