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Table 2 Gene list predicting sensitivity (S) or resistance (R) to PG-11047 treatment.

From: A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047

Gene symbol P-value Predict Chromosome location Gene name Function References
WASL 2.5E-05 R chr7q31.3 Wiskott-Aldrich syndrome-like Key regulator of cell migration and actin polymerization by interaction with Ap2/3 complex [32, 47]
GCLM 4.7E-05 S chr1p22.1 Glutamate-cysteine ligase, modifier subunit Regulatory subunit of glutamate-cystein ligase, a rate-limiting enzyme catalyzing the first step of GSK biosynthesis from cysteine [39]
CST3 6.3E-05 R chr20p11.21 Cystatin C (amyloid angiopathy and cerebral haemorrhage) Potent inhibitor of lysosomal proteinases. TGFβ receptor antagonist, inhibit epithelial-mesenchymal transition and morphological transformation [30]
LAMA3 6.7E-05 S chr18q11.2 Laminin, alpha 3 Component of laminin 5, the major extracellular metrix protein produced in the basement membrane of the mammary epithelial cells. Induces motility, invasion and epithelial-mesenchymal transition [35, 48]
SSRP1 1.2E-04 S chr11q12 Structure specific recognition protein 1 Histone chaperone. Forms a heterodimer with Spt16 and is a component of the chromatin transcript regulation factor, FACT [40, 42]
ACYP1 1.2E-04 S chr14q24.3 Acylphosphatase 1, erythrocyte (common) type Catalyze the hydroolysis of acylphosphates [49]
CYLD 2.9E-04 S chr16q12.1 Cylindromatosis (turban tumour syndrome) A deubiquinating enzyme that negatively regulate the activity of NFkB and JNK. Regulate mitotic entry [43, 45]
PRPF18 3.0E-04 S chr10p13 PRP18 pre-mRNA processing factor 18 homolog (Saccharomyces cerevisiae) Participate in pre-mRNA splicing, prepare mRNA for translation [41]
AMFR 3.1E-04 S chr16q21 Autocrine motility factor receptor Receptor for AMF, a tumour motility-stimulating protein secreted by tumour cells. Stimulation of AMFR by AMF alters cellular adhesion, proliferation, motility and apoptosis [33, 36]
DEAF1 7.9E-04 R chr11p15.5 Deformed epidermal autoregulatory factor 1 (Drosophila) A sequence-specific DNA-binding protein required for development. May be a general regulator of gene transcription/expression. DEAF1 (also called 'suppressin') appear to be mutated in tumours and cell lines [50, 51]
PPP1R2 1.5E-03 S chr3q29 Protein phosphatase 1, regulatory (inhibitor) subunit 2 Inhibitor of protein phosphatase 1. Phosphorylation of PPP1R2 by glycogen synthase kinase-3 (GSK3) activates the enzyme. PPP1R2 (INH2) regulates PP1 complexed with NEK2 to induce centrosome separation [44]
LOH11CR2A 1.7E-03 S chr11q23 Loss of heterozygosity, 11, chromosomal region 2, gene A Frequent loss of heterozygosity at 11q23 region found in many tumour types [46]
ACSL3 1.8E-03 R chr2q34-q35 Acyl-CoA synthetase long-chain family member 3 Essential for fatty acid metabolism, providing activated intermediates for complex lipid synthesis, protein modification, and beta oxidation [52]