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Figure 1 | BMC Medicine

Figure 1

From: The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo

Figure 1

Tumor formation and extracellular matrix molecules (ECM)/cytokine analyses of premenopausal African-American and Caucasian-American breast fibroblasts. (a) Hematoxylin and eosin (H&E) staining of murine mammary glands humanized with African-American (AA) or Caucasian-American (CAU) fibroblasts. (b,c) Humanized murine mammary glands were injected with either primary metastatic breast cancer or T47D cells. Data represent mean ± SD of final tumor volume. (d,e) Quantitative real-time PCR analysis: primary human breast fibroblasts were isolated from fresh reduction mammoplasty breast tissue. RNA was isolated and analyzed via quantitative real-time PCR. Individual patient samples (n = 18) were used to validate array results with newly designed primers to the indicated genes. Data represent fold increase ± standard error of differentially regulated genes. *P < 0.05

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