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Table 2 Summary of studies using GDF-15 for risk stratification of AMI

From: Biomarkers in acute myocardial infarction

Study Pop N Endpoints Thresholds Odds ratio or Hazard Ratio Ref
GUSTOIV (NSTEACS) 2,081 + 429 Death (one year) Tertiles < 1,200 ng/L, 1,200 to 1,800 ng/L > 1,800 ng/L 1.5%, 5%, 14.1% [46]
FRISC-II (invasive vs conservative) 2,079 Death or MI (2 yrs) Invasive at > 1,800 ng/L Invasive 1,200 to 1,800 ng/L Invasive < 1,200 or Trop -ve HR 0.49 (risk reduction) HR 0.68 No benefit [47]
ASSENT-2/plus (STEMI) 741 Death (1 yr) Tertiles < 1,200, 1,200 to 1,800, > 1,800 2.1%, 5.0%, 14% [48]
AMI 1,142 Death or HF (1.5 yr) <1,470 ng/L, >1,470 ng/L HR 1.77 [49]