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Table 4 Univariate and multivariate (backward conditional selection) Cox regression analysis of metastasis-free survival (MFS) in breast cancer patients considering clinicopathological characteristics, tumour microvessel density and hypoxia inducible factor 1α (HIF-1α)TAGmRNA levels

From: Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer

Characteristics Univariate analysis of MFS,
Exp B (95% CI)
Pvalue Multivariate analysis of MFS,
Exp B (95% CI)
Pvalue
Age, years:     
< 50 1 0.561   
≥ 50 1.32 (0.52 to 3.37)    
Positive lymph node:     
0 1 0.003 1 0.005
1 to 3 8.00 (2.56 to 24.81)   5.56 (1.75 to 17.63)  
4 to 9 7.50 (1.70 to 30.00)   6.68 (1.48 to 30.14)  
> 10 1.20 (0.14 to 10.00)   0.48 (0.05 to 4.25)  
Pathological tumour size, mm:     
< 10 1 0.39   
10 to 20 1.10 (0.10 to 8.70)    
21 to 49 2.40 (0.30 to 18.90)    
> 50 2.70 (0.20 to 42.90)    
Tumour grade:     
1/2 vs 1 0.24   
3 1.70 (0.70 to 4.40)    
Peritumoural vascular invasion:     
Absent 1 0.104   
Present 3.40 (0.80 to 14.80)    
OR status:     
Positive     
Negative 0.33 (0.13 to 0.85) 0.021   
PgR status:     
Positive     
Negative 0.20 (0.07 to 0.60) 0.005 0.23 (0.07 to 0.72) 0.012
Tumour microvessel density 1.02 (0.07 to 0.60) 0.22   
HIF-1α TAGmRNA levels 1.03 (1.00 to 1.05) 0.01   
  1. OR = oestrogen receptor; PgR = progesterone receptor, Exp B = exponential of beta