Table 5 Numeric codes describing the strength of evidence for an association of a gene with a disease.
Code | Kind of evidence |
|---|---|
6 | Known association of the gene with the disease. |
5 | Gene is known to interact with an intermediate, and the intermediate has a known association with the disease. |
4 | Known association of the gene with a function central to disease pathogenesis (for example, insulin secretion for diabetes). |
3 | Gene is known to interact with an intermediate, and the intermediate has a known association with a function central to disease pathogenesis. |
2 | Known association of a region containing the gene with the disease. |
1 | Gene disruption is known to have a general mutagenic effect. |
0 | No evidence. |