Skip to main content

Table 5 Numeric codes describing the strength of evidence for an association of a gene with a disease.

From: Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes

Code Kind of evidence
6 Known association of the gene with the disease.
5 Gene is known to interact with an intermediate, and the intermediate has a known association with the disease.
4 Known association of the gene with a function central to disease pathogenesis (for example, insulin secretion for diabetes).
3 Gene is known to interact with an intermediate, and the intermediate has a known association with a function central to disease pathogenesis.
2 Known association of a region containing the gene with the disease.
1 Gene disruption is known to have a general mutagenic effect.
0 No evidence.