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Table 2 Baseline Demographic and Clinical Characteristics Comparing ASA Low Responder and Responder

From: Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance - The BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy

Variable ASA Low-Responder ASA Responder OR (95% CI) p-Value
No. (%) 78 (19.4) 325 (80.6)   
Female gender (%) 19 (24.4) 101 (31.1) 0.71 (0.40-1.26) n.s. (0.27)
Age (years) 63.80 (12.90) 64.30 (11.70)   n.s. (0.74)
BMI (kg/m2) 28.17 (5.10) 27.81 (4.30)   n.s. (0.52)
EF (%) 52.78 (13.90) 54.35 (11.10)   n.s. (0.29)
Acute coronary syndrome 61 (78.2) 211 (64.9) 1.94 (1.08-3.48) 0.03
Arterial hypertension 62 (79.5) 258 (79.4) 1.01 (0.54-1.86) n.s. (1.0)
Diabetes mellitus 38 (48.7) 113 (34.8) 1.78 (1.08-2.94) 0.03
Lipid disorder 44 (56.4) 193 (59.4) 0.89 (0.54-1.46) n.s. (0.70)
Cigarette smoking 33 (42.3) 148 (45.5) 0.88 (0.53-1.45) n.s. (0.62)
Familial CAD disposition 10 (12.8) 68 (20.9) 0.56 (0.27-1.14) n.s. (0.11)
Beta-Blockers 71 (91.0) 279 (85.8) 1.67 (0.72-3.86) n.s. (0.27)
Nitrates 8 (10.3) 71 (21.8) 0.41 (0.19-0.89) 0.03
Calcium-channel blockers 25 (32.0) 90 (27.7) 1.23 (0.72-2.10) n.s. (0.49)
ACE Inhibitors 67 (85.9) 276 (84.9) 1.08 (0.53-2.19) n.s. (1.0)
Diuretics 39 (50.0) 124 (38.2) 1.62 (0.99-2.67) n.s. (0.07)
Statins 58 (74.4) 257 (79.1) 0.77 (0.43-1.36) n.s. (0.36)
Proton pump inhibitors 29 (37.2) 147 (45.2) 0.72 (0.43-1.19) n.s. (0.21)
Number of drugs (n ± SD) 7.50 (2.80) 7.48 (2.20) 1.67 (0.72-3.86) n.s. (0.95)
WBC (×109/l) 9.80 (4.10) 8.70 (5.40)   0.09
Hemoglobin (g/dl) 14.71 (2.40) 14.07 (1.50)   0.003
Platelet count (×109/l) 250.33 (10.22) 205.80 (63.69)   <0.001
Troponin positive (%) 34 (43.6) 53 (16.3) 3.97 (2.32-6.78) <0.001
CK max (U/l) 478.15 (1508.40) 529.77 (638.70)   n.s. (0.64)
Total cholesterol (mg/dl) 205.63 (60.60) 202.14 (51.30)   n.s. (0.60)
CRP (mg/l) 12.26 (21.40) 7.22 (15.40)   0.02
HbA1C (%) 6.88 (1.70) 6.41 (1.30)   0.007
D-dimer (mg/l) 0.78 (0.60) 1.02 (2.70)   n.s. (0.44)
Serum creatinine (mg/dl) 1.14 (0.80) 1.02 (0.30)   0.03
GFR (MDRD) (ml/min) 81.50 (59.70) 78.16 (22.30)   n.s. (0.42)
PREDICT score 3.39 (2.20) 2.55 (1.80)   <0.001
Clopidogrel low-response 44 (56.4) 74 (22.8) 4.39 (2.62-7.36) <0.001
  1. Data presented are mean ± SD and count (no.) or percentage (%). Calculation of p-values was done by unpaired t-test or chi-square test, comparing low-responder versus responder. OR = odds ratio; CI = confidence interval; n.s. = not significant.
  2. ASA = acetylsalicylic acid (aspirin), BMI = body mass index, EF = ejection fraction, CAD = coronary artery disease, ACE = angiotensin-converting enzyme, WBC = white blood cells, CK = creatine kinase, CRP = C-reactive protein, HbA1C = hemoglobin A1c, GFR = glomerular filtration rate.
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