Risk of infection in patients with lymphoma receiving rituximab: systematic review and meta-analysis

Table 5 The bivariate metaregression analysis to explore heterogeneity for leucopenia according mean age and line of treatment simultaneously.

Bivariate meta-regression model
Studies characteristics	Leucopenia
	Res.	Coeff. (CI 95%)	P
Mean age	0%	0.99 (0.96 to 1.01)	0.279
Previous treatment		1.59 (0.91 to 2.78)	0.084

The analysis confirms the results of subgroup analysis which indicates that the line of treatment is the best predictor of heterogeneity for severe leucopenia. Coeff. = regression coefficient in exponential form; Res. = residual heterogeneity

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