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Table 1 Meta-analysis results, odds ratios with corresponding 95% confidence intervals, heterogeneity metrics (P Q, I 2) and significance of the differential magnitude of effect in large versus small studies (P H) for allele contrast and dominant and recessive modelsa

From: Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system

Gene Study type Population Studies (n) Cases/Controls (n) OR (95% CI) I 2(%) (P Qvalue) P H
COL1A1 G2046T Allele contrast All 33 7,308/10,128 1.65 (1.39-1.94) 69 (<0.01) 0.01
   All in HWE 31 6,660/8,968 1.68 (1.41-2.01) 70 (<0.01) 0.01
   Caucasians 28 6,896/9,645 1.47 (1.29-1.68) 50 (<0.01) <0.01
   Adults 32 7,234/9,944 1.54 (1.33-1.78) 57 (<0.01) 0.01
   Female 21 5,942/8,104 1.37 (1.20-1.57) 40 (0.03) 0.05
   Postmenopausal 14 4,185/5,722 1.34 (1.14-1.58) 41 (0.06) 0.53
   Male 5 706/1,298 1.85 (1.09-3.14) 55 (0.06) 0.81
  Recessive model All 33 3,661/5,071 2.37 (1.78-3.16) 16 (0.21) 0.26
   All in HWE 31 3,337/4,491 2.37 (1.73-3.25) 20 (0.16) 0.16
   Caucasians 28 3,592/5,021 2.29 (1.76-3.00) 2 (0.43) 0.08
   Adults 32 3,661/5,071 2.24 (1.75-2.88) 0 (0.48) 0.18
   Female 21 3,300/4,373 2.00 (1.52-2.63) 0 (0.54) 0.65
   Postmenopausal 14 2,496/3,261 1.80 (1.29-2.50) 2 (0.43) 0.85
   Male 5 757/1,049 5.47 (2.31-12.95) 0 (0.57) 0.11
  Dominant model All 35 3,928/5,346 1.60 (1.34-1.91) 64 (<0.01) 0.01
   All in HWE 31 3,331/4,485 1.67 (1.37-2.03) 65 (<0.01) 0.03
   Caucasians 30 3,722/5,104 1.43 (1.23-1.65) 46 (<0.01) <0.01
   Adults 34 3,891/5,254 1.53 (1.30-1.81) 58 (<0.01) 0.02
   Female 23 3,245/4,334 1.37 (1.18-1.58) 36 (0.05) 0.02
   Postmenopausal 15 2,311/3,013 1.33 (1.12-1.58) 33 (0.10) 0.41
   Male 5 354/650 1.54 (0.81-2.93) 54 (0.07) 0.98
  Additive model All 33 2,487/3,658 2.64 (1.93-3.60) 24 (0.11) 0.13
   All in HWE 31 2,267/3,275 2.68 (1.90-3.78) 28 (0.08) 0.07
   Caucasians 28 2,447/3,626 2.46 (1.86-3.26) 9 (0.33) 0.03
   Adults 32 2,487/3,658 2.57 (1.94-3.41) 11 (0.29) 0.03
   Female 21 2,242/3,159 2.14 (1.59-2.89) 8 (0.35) 0.31
   Postmenopausal 14 1,694/2,399 1.94 (1.31-2.86) 20 (0.24) 0.55
   Male 5 547/843 5.18 (2.16-12.42) 0 (0.58) 0.20
  Codominant All 49 9,722/22,924 1.17 (1.04-1.31) 69 (<0.01) 0.13
   All in HWE 31 3,331/4,485 1.33 (1.11-1.60) 57 (<0.01) 0.31
   Caucasians 44 9,516/22,682 1.12 (1.01-1.26) 68 (<0.01) 0.14
   Adults 48 9,685/22,832 1.17 (1.04-1.31) 69 (<0.01) 0.13
   Female 30 7,497/16,464 1.12 (0.99-1.26) 62 (<0.01) 0.38
   Postmenopausal 15 3,290/6,530 1.16 (0.98-1.37) 36 (0.08) 0.26
   Male 12 1,896/6,098 1.07 (0.80-1.44) 78 (<0.01) 0.29
COL1A1 G-1997T Allele contrast All 3 778/852 1.38 (1.05-1.81) 0 (0.94) 0.11
  Recessive model All 3 389/426 1.66 (0.67-4.11) 0 (0.70) 0.95
  Dominant model All 3 389/426 1.42 (1.04-1.93) 0 (0.88) 0.53
  Additive model All 3 279/330 1.08 (0.72-4.49) 0 (0.73) 0.93
  Codominant All 3 389/426 1.36 (0.99-1.87) 0 (0.73) 0.71
COL1A1 -1663T ins/del Allele contrast All 3 776/850 1.03 (0.81-1.33) 0 (0.73) 0.14
  Recessive model All 3 388/425 1.81 (0.87-3.71) 0 (0.78) 0.11
  Dominant model All 3 388/425 0.94 (0.70-1.26) 0 (0.49) 0.09
  Additive model All 3 283/295 1.74 (0.84-3.58) 0 (0.86) 0.20
  Codominant All 3 388/425 0.82 (0.58-1.15) 12 (0.32) 0.06
COL1A1 MspI 26 kb upstream (mt-/wt+) Allele contrast All 2 318/312 1.33 (0.95-1.86) NA (0.86) NA
  Recessive model All 2 159/156 1.44 (0.69-2.98) NA (0.51) NA
  Dominant model All 2 159/156 1.43 (0.91-2.23) NA (0.92) NA
  Additive model All 2 88/94 1.66 (0.78-3.56) NA (0.50) NA
  Codominant All 2 159/156 1.25 (0.79-1.97) NA (0.87) NA
COL1A1 RsaI intron 5 (mt-/wt+) Allele contrast All 2 318/312 1.03 (0.37-2.91) NA (0.01) NA
  Recessive model All 2 159/156 0.85 (0.27-2.66) NA (0.47) NA
  Dominant model All 2 159/156 1.09 (0.29-4.19) NA (<0.01) NA
  Additive model All 2 96/103 0.90 (0.23-3.42) NA (0.25) NA
  Codominant All 2 159/156 1.13 (0.33-3.89) NA (0.01) NA
COL1A1 MnII exon 52 (mt-/wt+) Allele contrast All 2 318/312 0.77 (0.55-1.07) NA (0.41) NA
  Recessive model All 2 159/156 0.70 (0.18-2.75) NA (0.07) NA
  Dominant model All 2 159/156 0.78 (0.50-1.22) NA (0.84) NA
  Additive model All 2 96/93 0.63 (0.20-2.00) NA (0.14) NA
  Codominant All 2 159/156 0.95 (0.47-1.93) NA (0.12) NA
IGF-I 192 bp CA (mt-/wt+) Dominant model All 2 47/136 0.70 (0.15-3.35) NA (0.03) NA
ITGB3 T176C Allele contrast All 2 534/17,932 1.23 (0.87-1.76) NA (0.11) NA
  Recessive model All 2 267/8,966 1.88 (1.06-3.33) NA (0.76) NA
  Dominant model All 2 267/8,966 1.20 (0.76-1.90) NA (0.09) NA
  Additive model All 2 192/6,517 1.93 (1.09-3.45) NA (0.58) NA
  Codominant All 2 267/8,966 1.09 (0.68-1.72) NA (0.10) NA
  1. aOR, odds ratio; 95% CI, 95% confidence interval; I 2, quantification of heterogeneity; P Q, P-value for heterogeneity; P H, P-value for magnitude of effect in large versus small studies; COL1A1, collagen, type I, α1; NA, not applicable; HWE, Hardy-Weinberg equilibrium; mt, mutant type; wt, wild type; IGF-I, insulin-like growth factor I; ITGB3, integrin β-chain β3.