Table 4 Characteristics of participants in the prospective mortality prediction cohort according to different LFS thresholds

Age, years

39.23

38.34 to 40.13

45.50

44.28 to 46.71

45.04

42.78 to 47.29

<0.001

Sex, female %

56.40

54.1 to 58.7

42.30

39.3 to 45.3

45.70

38.1 to 53.5

<0.001

Race/ethnicity, %

<0.001

Non-Hispanic white

78.40

75.5 to 81.1

74.10

69.3 to 78.4

73.30

68.0 to 78.0

<0.001

Non-Hispanic black

10.30

8.9 to 11.8

10.50

8.8 to 12.5

10.90

8.6 to 13.7

<0.001

Mexican-American

4.20

3.5 to 5.1

6.40

5.1 to 8.0

7.80

5.3 to 11.2

<0.001

Other

7.10

5.4 to 9.3

9.00

5.9 to 13.4

8.00

5.6 to 11.5

<0.001

Education, %

<0.001

< High school

4.10

3.2 to 5.2

8.20

6.0 to 11.0

8.10

5.5 to 11.7

<0.001

High school

13.30

11.7 to 15.0

18.80

15.6 to 22.4

16.80

13.8 to 20.3

<0.001

> High school

82.60

80.3 to 84.7

73.10

68.4 to 77.3

75.10

70.1 to 79.6

<0.001

Smoking, %

<0.001

Never

49.20

46.2 to 52.3

41.00

37.3 to 44.8

47.90

40.3 to 55.5

<0.001

Former

21.60

19.6 to 23.7

33.20

29.5 to 37.1

32.30

25.9 to 39.5

<0.001

Current

29.20

26.4 to 32.2

25.80

23.1 to 28.6

19.80

14.1 to 27.1

<0.001

Diabetes, %

0.20

0.1 to 0.3

5.70

4.6 to 7.0

26.20

21.3 to 31.7

<0.001

Hypertension, %

10.00

8.7 to 11.4

32.70

29.6 to 36.0

45.40

39.6 to 51.3

<0.001

Lipid-lowering medication, %

1.10

.7 to 1.8

5.40

4.1 to 7.1

7.20

4.4 to 11.6

<0.001

History of CVD, %

1.30

.9 to 1.9

3.40

2.4 to 4.8

5.10

3.1 to 8.2

<0.001

Poverty income ratio

3.25

3.09 to 3.4

2.98

2.76 to 3.2

2.83

2.54 to 3.11

0.003

Waist circumference, cm

85.22

84.74 to 85.71

100.22

99.52 to 100.92

112.22

110.51 to 113.93

<0.001

Dietary caffeine intake, mg

272.81

251.75 to 293.87

276.43

234.41 to 318.45

216.06

189.12 to 243

0.222

Serum cholesterol, mg/dl

196.06

194.01 to 198.11

213.02

209.91 to 216.14

218.33

211.56 to 225.1

<0.001

Serum HDL cholesterol, mg/dl

53.38

52.51 to 54.25

43.81

42.74 to 44.89

39.06

37.89 to 40.23

<0.001

Serum transferrin saturation, %

27.78

27.25 to 28.31

26.25

25.55 to 26.95

25.54

23.88 to 27.2

<0.001

Serum C-reactive protein, mg/dl

0.33

0.31 to 0.35

0.45

0.42 to 0.49

0.58

0.5 to 0.66

<0.001

Drinks/week^a

2.68

2.45 to 2.9

2.32

2.01 to 2.64

1.62

1.11 to 2.13

<0.001

LFS

-2.53

-2.58 to -2.48

-0.41

-0.46 to -0.36

3.20

2.83 to 3.57

<0.001

Mortality

All causes

8.90

7.7 to 10.2

13.60

11.4 to 16.2

17.70

12.9 to 23.9

<0.001

CVD-related

2.80

2.3 to 3.5

5.10

4.0 to 6.4

9.00

5.4 to 14.8

<0.001

Liver-related

0.10

0.0 to 0.3

0.10

0.0 to 0.2

1.20

0.3 to 5.2

0.069

Diabetes-related

0.20

0.1 to 0.5

0.90

0.6 to 1.5

3.90

2.0 to 7.4

<0.001

Malignancy-related

2.80

2.1 to 3.8

3.60

2.5 to 5.2

2.00

1.0 to 4.2

0.698