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Table 3 Sensitivity analysis for evaluating bias due to comorbidity

From: Visit-to-visit variability of fasting plasma glucose as predictor of ischemic stroke: competing risk analysis in a national cohort of Taiwan Diabetes Study

  

Ischemic stroke HR (95%CI)

  

FPG-CV (%)

Modela

Number

≥14.1

14.1 to 25.2

25.2 to 42.0

>42.0

Model I

27,999

1.00

1.10 (0.97, 1.24)

1.21 (1.08, 1.37)**

1.27 (1.12, .144)***

Model II

28,138

1.00

1.12 (0.99, 1.26)

1.22 (1.09, 1.38)**

1.27 (1.13, 1.44)***

Model III

27,701

1.00

1.12 (0.99, 1.27)

1.22 (1.08, 1.38)**

1.27 (1.12, 1.44)***

Model IV

28,239

1.00

1.11 (0.98, 1.26)

1.22 (1.08, 1.37)**

1.28 (1.13, 1.44)***

Model V

28,274

1.00

1.11 (0.98, 1.26)

1.22 (1.08, 1.38)**

1.27 (1.13, 1.44)***

Model VI

27,008

1.00

1.12 (0.99, 1.27)

1.22 (1.08, 1.38)**

1.29 (1.14, 1.46)***

  

HbA1c (%)

Model a

Number

<7.0

7.0 to 8.0

8.0 to 9.0

≥9.0

Model I

27,999

1.00

1.15 (1.02, 1.30)*

1.34 (1.18, 1.53)***

1.67 (1.47, 1.90)***

Model II

28,138

1.00

1.14 (1.01, 1.28)*

1.33 (1.17, 1.51)***

1.67 (1.46, 1.89)***

Model III

27,701

1.00

1.13 (1.00, 1.28)*

1.33 (1.16, 1.51)***

1.68 (1.48, 1.91)***

Model IV

28,239

1.00

1.13 (1.00, 1.28)*

1.34 (1.17, 1.52)***

1.68 (1.48, 1.91)***

Model V

28,274

1.00

1.15 (1.02, 1.30)*

1.34 (1.18, 1.52)***

1.70 (1.49, 1.92)***

Model VI

27,008

1.00

1.14 (1.01, 1.29)*

1.36 (1.19, 1.55)***

1.69 (1.48, 1.93)***

  1. *P <0.05; **P <0.01; ***P <0.001. Multivariate-adjusted afor age, gender, tobacco, alcohol, duration of diabetes, hypoglycemic drugs, hypertension drug treatment, obesity, coronary artery disease, congestive heart failure, cancer, hyperlipidemia, hypertension, atrial fibrillation, chronic hepatitis, chronic obstructive pulmonary disease and estimated glomerular filtration rate (eGFR). Model I excluding patients with hyperglycemic hyperosmolar nonketotic coma (HHNK) (Number = 355). Model II excluding patients with diabetic ketoacidosis (DKA) (Number = 216). Model III excluding patients with myocardial infarction (Number = 653). Model IV excluding patients with atrial fibrillation (Number = 115). CI: confidence interval; FPG-CV: coefficient of variation of fasting plasma glucose; HR: hazard ratio; HbA1c, glycated hemoglobin.
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