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Table 2 Relationship between rs9939609 polymorphism

From: FTOrs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients

Outcomes All patients TT AT AA P-value(a) aAMR (95%CI) P-value(b)
Continuous variables        
BMI (kg/m2) 23.29 ± 0.25 22.69 ± 0.35 22.91 ± 0.32 24.29 ± 0.58 0.016 1.08 (1.03; 1.14) 0.002
HOMA-IR 3.24 ± 0.19 2.97 ± 0.29 2.75 ± 0.26 4.19 ± 0.47 0.003 1.32 (1.03; 1.69) 0.027
  All patients TT AT AA P -value (a) aOR (95%CI) P -value (b)
Categorical variables        
Overweight (BMI ≥27.5 kg/m2) 8.5% (22/260) 4% (4/100) 8.9% (11/123) 19.4% (7/36) 0.011 3.46 (1.17; 10.21) 0.024
HOMA-IR ≥2.5 41.4% (108/261) 38.6% (39/101) 39% (48/123) 56.8% (21/37) 0.040 2.09 (1.02; 4.32) 0.045
Significant fibrosis (F ≥ 2) 48.6% (102/210) 48.8% (41/84) 43.3% (42/97) 65.5% (19/29) 0.049 2.34 (1.02; 5.36) 0.045
Steatosis (>10% fatty hepatocytes) 56.9% (115/202) 51.9% (41/79) 57% (53/93) 70% (21/30) 0.117 3.65 (1.29;10.36) 0.015
  1. a P-values were calculated by Chi-square tests for categorical variables and generalized linear models (GLM) with normal distribution (log-link) for continuous variables; b P-values were calculated by GLM adjusted by the most important clinical and epidemiological characteristics (see Statistical analysis section). Metabolic disturbances and liver disease in HIV/HCV-coinfected patients. Categorical variables are expressed in percentage (absolute count) and continuous variables are expressed in estimated marginal mean ± standard error of the mean. Statistically significant differences are shown in bold. 95%CI, 95% confidence interval; aAMR, adjusted arithmetic mean ratio; aOR, adjusted odds ratio; BMI, body mass index; HCV, hepatitis C virus; HIV, human immunodeficiency virus; HOMA-IR, homeostatic model assessment-insulin resistance.