Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study

Table 5 The levels of thyroid hormone profiles in newborns conceived by natural conception (NC), fresh embryo transfer (ET), and frozen ET

	NC	Fresh ET	Frozen ET	Fresh ET vs. NC	Fresh ET vs. Frozen ET	Frozen ET vs. NC
	(n = 80)	(n = 55)	(n = 48)	Crude P	Crude P	Crude P
	(n = 80)	(n = 55)	(n = 48)	(Adjusted P )	(Adjusted P )	(Adjusted P )
T3 (nmol/L)	2.09 ± 0.44	2.13 ± 0.47	1.94 ± 0.65	0.60 (0.66)	0.09 (0.09)	0.18 (0.10)
FT3 (pmol/L)	4.93 ± 0.92	5.07 ± 1.25	5.02 ± 1.57	0.43 (0.43)	0.85 (0.84)	0.52 (0.67)
T4 (nmol/L)	98.41 ± 14.71	107.65 ± 18.93	99.69 ± 21.43	<0.01 (<0.01)	0.03 (0.03)	0.69 (0.73)
FT4 (pmol/L)	15.66 ± 1.97	16.50 ± 1.76	16.39 ± 2.47	0.01 (0.01)	0.82 (0.82)	0.04 (0.07)
TSH (mIU/L)	2.69 ± 0.99	3.15 ± 1.01	2.76 ± 1.00	<0.01 (0.01)	0.03 (0.03)	0.91 (0.78)

Data are shown as mean ± SD.
Log transformations were conducted when the normality assumption was not satisfied. Adjusted P values were calculated by linear regression adjusted for sex of newborn.

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