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Figure 1 | BMC Medicine

Figure 1

From: In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver

Figure 1

Schematic diagrams showing of regions in which methylation was assessed including IGF2 and exons 1(F) and 1(C) of theGRpromoter. (A) The IGF2 gene comprises multiple transcripts originating from promoters (P0-P4) which splice into common protein-coding exons (shaded in grey). The H19 ICR is situated distal to IGF2. Regions of differential methylation are shown underlined. (B) The GR gene also comprises multiple alternate untranslated first exons as indicated (B-H) [33]. Percentage methylation was assessed at CpGs within exons 1F, 1-C1 and 1-C3.

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BMC Medicine

ISSN: 1741-7015

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