From: Seeking effective interventions to treat complex wounds: an overview of systematic reviews
Outcome | Intervention | Systematic reviews with MA | Systematic reviews without MA | ||
---|---|---|---|---|---|
High-quality* | Low/moderate quality | High-quality** | Low/moderate quality | ||
Autologous platelet-rich plasma/platelet-rich plasma (topical) | – | – | NA | NA | |
Silver releasing dressings | + | NA | NA | NA | |
Topical negative pressure | NA | + | NA | NA | |
Laser therapy | NA | – | NA | NA | |
Adhesive zinc oxide tape | NA | NA | + | NA | |
 | Dextranomer polysaccharide beads or paste, cadexomer iodine polysaccharide beads or paste | NA | NA | _ | NA |
 | Enzymatic agents (topical) | NA | NA | – | NA |
 | Hydrogel dressings | NA | NA | – | NA |
 | Hyperbaric oxygen therapy | NA | NA | NA | + |
 | No-sting barrier film bandages | NA | NA | NA | + |
 | Silver releasing dressing, non-releasing silver-activated charcoal dressing, hydrocolloid silver Vaseline-impregnated dressing, silver coated dressing, hydrocolloid silver-releasing dressing, silver-releasing foam dressing | NA | NA | + | NA |
 | Topical negative pressure (open-cell foam dressing with continuous suction) | NA | NA | + | NA |
Proportion of patients with healed wounds (MAs: 10) [21,55,58,61,62,125] | Skin replacement (skin substitute) and standard care | NA | + | NA | NA |
Skin replacement (dermal substitute) and standard care | NA | + | NA | NA | |
Artificial skin grafts and standard care | NA | + | NA | NA | |
 | Autologous platelet-rich plasma/platelet-rich plasma (topical) | NA | – | NA | NA |
 | Hydrocolloid dressings | – | + | NA | NA |
 | Laser therapy | – | NA | NA | NA |
 | Ultrasound | +/− | NA | NA | NA |