Age-group (years) | Outcome/Design | Â | No of studies included | Crude OR (95% CI) | I 2 | No of studies included | Adjusted OR (95% CI) | I 2 | No of studies included | Off-season adjusted OR (95% CI) | I 2 |
---|---|---|---|---|---|---|---|---|---|---|---|
0–17 | No studies | 0 | – | – | 0 | – | – | 0 | – | – | |
18–64 | All-cause mortality |  |  |  |  |  |  |  |  |  | |
 |  | Case–control studies | 1 | 0.46 (0.11–1.89) | NA1 | 1 | 0.76 (0.07–8.06) | NA1 | 0 | – | NA1 |
 | All-cause hospitalization |  |  |  |  |  |  |  |  |  | |
 |  | Case–control studies | 2 | 0.32 (0.19–0.54) | 0% | 3 | 0.42 (0.19–0.94) | 77% | 1 | 0.73 (0.65–0.83) | NA1 |
 | Influenza/pneumonia hospitalization |  |  |  |  |  |  |  |  | ||
 |  | Case–control studies | 0 | – | – | 1 | 0.57 (0.46–0.72) | NA1 | 1 | 0.88 (0.68–1.14) | NA1 |
 | Influenza-like illness |  |  |  |  |  |  |  |  |  | |
 |  | Cohort studies | 1 | 0.76 (0.50–1.15) | NA1 | 0 | – | – | 0 | – | – |
 |  | Case–control studies | 0 | – | – | 1 | 0.99 (0.97–1.01) | NA1 | 1 | 1.00 (0.90–1.12) | NA1 |
≥65 | All-cause mortality |  |  |  |  |  |  |  |  |  | |
 |  | Cohort studies | 3 | 0.54 (0.37–0.79) | 90% | 2 | 0.62 (0.57–0.68) | 0% | 1 | 0.70 (0.37–1.31) | NA1 |
 |  | Case–control studies | 2 | 0.39 (0.35–0.43) | 0% | 2 | 0.44 (0.36–0.53) | 0% | 0 | – | – |
 | All-cause hospitalization |  |  |  |  |  |  |  |  |  | |
 |  | Cohort studies | 1 | 0.83 (0.72–0.95) | NA1 | 0 | – | – | 1 | 0.91 (0.71–1.17) | NA1 |
 |  | Case–control studies | 2 | 0.89 (0.81–0.98) | 0% | 3 | 0.77 (0.60–0.99) | 94% | 1 | 0.66 (0.59–0.74) | NA1 |
 | Influenza/pneumonia hospitalization |  |  |  |  |  |  |  |  | ||
 |  | Case–control studies | 1 | 0.20 (0.07–0.61) | NA1 | 1 | 0.55 (0.47–0.66) | NA1 | 1 | 0.48 (0.32–0.70) | NA1 |
 | Influenza-like illness |  |  |  |  |  |  |  |  |  | |
 |  | Case–control studies | 0 | – | – | 1 | 0.87 (0.84–0.90) | NA1 | 1 | 0.82 (0.70–0.96) | NA1 |
Not reported | Influenza/pneumonia hospitalization | Â | Â | Â | Â | Â | Â | Â | Â | ||
 |  | Cohort studies | 1 | 1.75 (0.10–32.68) | NA1 | 0 | – | – | 0 | – | – |
 | Influenza-like illness |  |  |  |  |  |  |  |  |  | |
 |  | Cohort studies | 1 | 0.34 (0.02–5.85) | NA1 | 0 | – | – | 0 | – | – |