Table 1 Studies included in the meta-analysis

Adjuik-2002

390

Multicentric

6-59

12 & 30

Sanofi-Synthélabo & Parke-Davis

Loose NFDC

Full

[8]

Anvikar-2012 ^b

199

India

6-720

12 & 30

Sanofi-Aventis

FDC

Full

[36]

Barennes-2004

32

Burkina Faso

12-180

12 & 30

Sanofi Winthrop AMO & Hoechst Marion Roussel

Loose NFDC

Full

[64]

Bonnet-2007

110

Guinea

6-59

12 & 30

Guilin Pharmaceutical & Parke-Davis

Loose NFDC

Full

[65]

Brasseur-2009 ^b

276

Senegal

All ages

N/A

Sanofi-Aventis

Co-blistered NFDC

Full/partial^e

[17]

Bukirwa-2006

203

Uganda

12-120

12 & 25

Sanofi-Aventis & Parke-Davis, Pfizer

Loose NFDC

Full

[66]

Dorsey-2007

145

Uganda

12-120

12 & 25

Sanofi-Aventis & Pfizer

Loose NFDC

Full

[67]

Espié-2012

149

DRC

6-59

12 & 30

Sanofi-Aventis

FDC

Full

[34]

Faucher-2009

94

Benin

6-60

12 & 30

Sanofi-Aventis

FDC

Partial

[68]

Faye-2010

155

Multicentric

>84

N/A

Pfizer

Co-blistered NFDC

Full

[69]

Gaye-2010b ^d

129

Senegal

12-720

12 & 30

Sanofi-Aventis

FDC

Full

[Unpublished]

Grandesso-2003 ^d

86

Uganda

6-59

12 & 30

Sanofi & Park-Davis

Loose NFDC

Full

[Unpublished]

Grandesso-2006

123

Sierra Leone

6-59

12 & 30

Sanofi Winthrop AMO & Pfizer

Loose NFDC

Full

[44]

Guthmann-2005

96

Angola

6-59

12 & 30

Sanofi Winthrop & Parke Davis

Loose NFDC

Full

[70]

Guthmann-2006

68

Angola

6-59

12 & 30

Sanofi Winthrop & Parke Davis

Loose NFDC

Full

[71]

Hamour-2005

71

Sudan

6-59

12 & 30

Sanofi & Park-Davis

Loose NFDC

Full

[72]

Hasugian-2007

93

Indonesia

>12

12 & 30

Guilin Pharmaceuticals & Aventis

Loose NFDC

Full

[6]

Jullien-2010

27

Kenya

216-720

N/A

Sanofi-Aventis

Co-blistered NFDC

Full

[73]

Jullien-2010

24

Kenya

216-720

12 & 30

Sanofi-Aventis

FDC

Full

[73]

Juma-2005 ^d

201

Kenya

6-59

12 & 30

Sanofi-Aventis

Loose NFDC

Full

[Unpublished]

Karema-2006

251

Rwanda

12-59

12 & 30

Sanofi-Aventis

Loose NFDC

Full

[74]

Kayentao-2009

128

Mali

6-59

12 & 30

-

Co-blistered NFDC

Full

[75]

Laminou-2011 ^d

80

Niger

6-180

12 & 30

Sanofi-Aventis

FDC

Partial

[Unpublished]

Mårtensson-2005

202

Tanzania

6-59

12 & 30

Mepha & Roussel

Loose NFDC

Full

[45]

Menan-2012 ^d

110

Ivory Coast

12-480

12 & 30

Sanofi-Aventis

FDC

Full

[Unpublished]

Menard-2008

332

Madagascar

6-180

12 & 30

-

Loose NFDC

Full

[76]

Ndiaye-2009

625

Multicentric

All ages

12 & 30

Sanofi-Aventis

FDC

Full

[30]

Ndiaye-2011

179

Senegal

All ages

12 & 30

Sanofi-Aventis

FDC

Full^f

[32]

Nikiema-2010 ^d

527

Burkina Faso

6-120

12 & 30

Sanofi-Aventis

FDC

Full

[Unpublished]

Osorio-2007

37

Columbia

12-780

12 & 30

Sanofi-Aventis

Loose NFDC

Full

[77]

Rwagacondo-2004

157

Rwanda

6-59

12 & 30

Dafra

Loose NFDC

Full

[11]

Sagara-2012

230

Mali

≥6

12 & 30

Sanofi-Aventis

Co-blistered NFDC

Full

[78]

Sanofi-2013 ^d

203

Uganda

6-59

12 & 30

Sanofi-Aventis

FDC

Full^f

[Unpublished]

Schramm-2013

147

Liberia

6-72

12 & 30

Sanofi-Aventis

FDC

Full

[38]

Sinou-2009 ^c

13

Congo

≥192

12 & 30

Saokim Pharmaceuticals Co

FDC

Full

[31]

Sirima-2009 ^b

441

Burkina Faso

6-59

12 & 30

Sanofi-Aventis

Co-blistered NFDC

Full

[18]

Sirima-2009 ^b

437

Burkina Faso

6-59

12 & 30

Sanofi-Aventis

FDC

Full

[18]

Smithuis-2010

142

Myanmar

>6

12 & 32/4

Sanofi-Aventis

FDC

Partial

[7]

Staedke-2004

130

Uganda

6-120

12 & 25

Sanofi-Pfizer

Loose NFDC

Full

[79]

Swarthout-2006

82

DRC

6-59

12 & 30

Sanofi and Parke Davis & Pfizer

Loose NFDC

Full

[80]

Temu-2010 ^d

99

Liberia

6-60

12 & 30

Sanofi-Aventis

FDC

Full

[Unpublished]

The 4ABC StudyGroup-2011

981

Multicentric

6-59

12 & 30

Sanofi-Aventis

FDC

Full

[15]

Thwing-2009

101

Kenya

6-59

12 & 25

Cosmo Pharmaceuticals & Pfizer

Loose NFDC

Full

[46]

van den Broek-2006

87

Congo

6-59

12 & 30

Cosmo Pharmaceuticals & Pfizer

Loose NFDC

Full

[81]

Yeka-2005

714

Uganda

≥6

12 & 25

Sanofi-Pfizer

Loose NFDC

Full

[82]