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Table 1 Studies included in the meta-analysis

From: The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data

Study a Number of patients treated with AS-AQ Country Age range (months) Target dose (mg/kg) for artesunate & amodiaquine Manufacturer Formulation Supervision Reference
Adjuik-2002 390 Multicentric 6-59 12 & 30 Sanofi-Synthélabo & Parke-Davis Loose NFDC Full [8]
Anvikar-2012 b 199 India 6-720 12 & 30 Sanofi-Aventis FDC Full [36]
Barennes-2004 32 Burkina Faso 12-180 12 & 30 Sanofi Winthrop AMO & Hoechst Marion Roussel Loose NFDC Full [64]
Bonnet-2007 110 Guinea 6-59 12 & 30 Guilin Pharmaceutical & Parke-Davis Loose NFDC Full [65]
Brasseur-2009 b 276 Senegal All ages N/A Sanofi-Aventis Co-blistered NFDC Full/partiale [17]
Bukirwa-2006 203 Uganda 12-120 12 & 25 Sanofi-Aventis & Parke-Davis, Pfizer Loose NFDC Full [66]
Dorsey-2007 145 Uganda 12-120 12 & 25 Sanofi-Aventis & Pfizer Loose NFDC Full [67]
Espié-2012 149 DRC 6-59 12 & 30 Sanofi-Aventis FDC Full [34]
Faucher-2009 94 Benin 6-60 12 & 30 Sanofi-Aventis FDC Partial [68]
Faye-2010 155 Multicentric >84 N/A Pfizer Co-blistered NFDC Full [69]
Gaye-2010b d 129 Senegal 12-720 12 & 30 Sanofi-Aventis FDC Full [Unpublished]
Grandesso-2003 d 86 Uganda 6-59 12 & 30 Sanofi & Park-Davis Loose NFDC Full [Unpublished]
Grandesso-2006 123 Sierra Leone 6-59 12 & 30 Sanofi Winthrop AMO & Pfizer Loose NFDC Full [44]
Guthmann-2005 96 Angola 6-59 12 & 30 Sanofi Winthrop & Parke Davis Loose NFDC Full [70]
Guthmann-2006 68 Angola 6-59 12 & 30 Sanofi Winthrop & Parke Davis Loose NFDC Full [71]
Hamour-2005 71 Sudan 6-59 12 & 30 Sanofi & Park-Davis Loose NFDC Full [72]
Hasugian-2007 93 Indonesia >12 12 & 30 Guilin Pharmaceuticals & Aventis Loose NFDC Full [6]
Jullien-2010 27 Kenya 216-720 N/A Sanofi-Aventis Co-blistered NFDC Full [73]
Jullien-2010 24 Kenya 216-720 12 & 30 Sanofi-Aventis FDC Full [73]
Juma-2005 d 201 Kenya 6-59 12 & 30 Sanofi-Aventis Loose NFDC Full [Unpublished]
Karema-2006 251 Rwanda 12-59 12 & 30 Sanofi-Aventis Loose NFDC Full [74]
Kayentao-2009 128 Mali 6-59 12 & 30 - Co-blistered NFDC Full [75]
Laminou-2011 d 80 Niger 6-180 12 & 30 Sanofi-Aventis FDC Partial [Unpublished]
Mårtensson-2005 202 Tanzania 6-59 12 & 30 Mepha & Roussel Loose NFDC Full [45]
Menan-2012 d 110 Ivory Coast 12-480 12 & 30 Sanofi-Aventis FDC Full [Unpublished]
Menard-2008 332 Madagascar 6-180 12 & 30 - Loose NFDC Full [76]
Ndiaye-2009 625 Multicentric All ages 12 & 30 Sanofi-Aventis FDC Full [30]
Ndiaye-2011 179 Senegal All ages 12 & 30 Sanofi-Aventis FDC Fullf [32]
Nikiema-2010 d 527 Burkina Faso 6-120 12 & 30 Sanofi-Aventis FDC Full [Unpublished]
Osorio-2007 37 Columbia 12-780 12 & 30 Sanofi-Aventis Loose NFDC Full [77]
Rwagacondo-2004 157 Rwanda 6-59 12 & 30 Dafra Loose NFDC Full [11]
Sagara-2012 230 Mali ≥6 12 & 30 Sanofi-Aventis Co-blistered NFDC Full [78]
Sanofi-2013 d 203 Uganda 6-59 12 & 30 Sanofi-Aventis FDC Fullf [Unpublished]
Schramm-2013 147 Liberia 6-72 12 & 30 Sanofi-Aventis FDC Full [38]
Sinou-2009 c 13 Congo ≥192 12 & 30 Saokim Pharmaceuticals Co FDC Full [31]
Sirima-2009 b 441 Burkina Faso 6-59 12 & 30 Sanofi-Aventis Co-blistered NFDC Full [18]
Sirima-2009 b 437 Burkina Faso 6-59 12 & 30 Sanofi-Aventis FDC Full [18]
Smithuis-2010 142 Myanmar >6 12 & 32/4 Sanofi-Aventis FDC Partial [7]
Staedke-2004 130 Uganda 6-120 12 & 25 Sanofi-Pfizer Loose NFDC Full [79]
Swarthout-2006 82 DRC 6-59 12 & 30 Sanofi and Parke Davis & Pfizer Loose NFDC Full [80]
Temu-2010 d 99 Liberia 6-60 12 & 30 Sanofi-Aventis FDC Full [Unpublished]
The 4ABC StudyGroup-2011 981 Multicentric 6-59 12 & 30 Sanofi-Aventis FDC Full [15]
Thwing-2009 101 Kenya 6-59 12 & 25 Cosmo Pharmaceuticals & Pfizer Loose NFDC Full [46]
van den Broek-2006 87 Congo 6-59 12 & 30 Cosmo Pharmaceuticals & Pfizer Loose NFDC Full [81]
Yeka-2005 714 Uganda ≥6 12 & 25 Sanofi-Pfizer Loose NFDC Full [82]
  1. aFull details of the references and study design are available in Additional file 1: Text S1.
  2. bThe dose was given based on age bands for these studies. For the rest of the studies, dosing was based on weight categories.
  3. cAll patients recruited given 2 doses/day.
  4. dThese studies are unpublished.
  5. eFully supervised between 2002-2004 and partially supervised in 2005.
  6. fThe first episodes of malaria were fully supervised in these studies.