|  | Univariable analysis | Multivariable analysis b | Population attributable risk c | |||
---|---|---|---|---|---|---|---|
(N = 9,058) | |||||||
Variable | Total n [ n ] a | Crude HR [95% CI] | p -Value | Adjusted HR [95% CI] | P -Value | Freq. | PAR |
Age (y) | 9,095 (265) | 0.92 [0.89-0.96] | <0.001 | - | - | - | - |
Amodiaquine dose (5Â mg/kg) | 9,095 (265) | 0.94 [0.84-1.04] | 0.220 | 0.94 [0.84-1.05] | 0.280 | - | - |
Enrolment clinical variables | Â | Â | Â | Â | Â | Â | Â |
Parasitemia (per 10-fold) | 9,095 (265) | 1.46 [1.16-1.84] | 0.001 | 1.39 [1.1-1.74] | 0.005 | 10.4% | 3.7% |
Parasitemia >100,000 parasites/μl | 9,095 (265) | 1.41 [0.98-2.05] | 0.066 | - | - | - | - |
Fever (temp > 37.5°C) | 8,755 (252) | 1.05 [0.78-1.41] | 0.760 | - | - | - | - |
Hemoglobin (g/dl) | 6,895 (237) | 0.93 [0.87-1.00] | 0.055 | - | - | - | - |
Anemia (Hb < 10 g/dl) | 6,895 (237) | 1.37 [1.04-1.81] | 0.028 | - | - | - | - |
Gametocytes presence | 4,790 (99) | 1.04 [0.54-1.98] | 0.910 | - | - | - | - |
Underweight (WAZ < −2)d | 6,260 (616) | 0.87 [0.61-1.26] | 0.470 | - | - | - | - |
Gender | Â | Â | Â | Â | Â | Â | Â |
Female (reference) | 4,231 (126) | 1 | - | - | - | - | - |
Male | 4,702 (124) | 0.91 [0.71-1.16] | 0.450 | - | - | - | - |
Age category | Â | Â | Â | Â | Â | Â | Â |
≥12 y (reference) | 1,135 (12) | 1 | - | - | - | - | - |
<1 y | 782 (31) | 3.15 [1.46-6.78] | 0.004 | 3.93 [1.76-8.79] | 0.001 | 8.6% | 20.9% |
1 to <5 y | 5,645 (199) | 3.62 [1.83-7.18] | <0.001 | 4.47 [2.18-9.19] | <0.001 | 62.3% | 69.2% |
5 to <12 y | 1,533 (23) | 1.90 [0.91-3.98] | 0.088 | 2.03 [0.96-4.28] | 0.064 | 16.9% | 15.1% |
Drug formulation | Â | Â | Â | Â | Â | Â | Â |
FDC (reference) | 4,135 (70) | 1 | - | - | - | - | - |
Co-blistered NFDC | 1,256 (21) | 1.02 [0.52-2.00] | 0.950 | 1.38 [0.75-2.57] | 0.300 | 13.9% | 5.1% |
Loose NFDC-25 | 1,291(70) | 3.62 [1.79-7.30] | <0.001 | 3.51 [2.02-6.12] | <0.001 | 14.3% | 25.8% |
Loose NFDC-30e | Â | Â | Â | Â | Â | Â | Â |
In Rukara/Kailahun/Kisumuf | 461 (59) | 8.41 [3.24-21.84] | <0.001 | 7.75 [4.07-14.76] | <0.001 | 5.1% | 26.3% |
Rest of the sites | 1,952 (45) | 1.34 [0.77-2.34] | 0.300 | 1.47 [0.91-2.38] | 0.110 | 21.1% | 8.3% |
Treatment supervision | Â | Â | Â | Â | Â | Â | Â |
Fully supervised (reference) | 8,530 (245) | 1 | - | - | - | - | - |
Partially supervised | 565 (20) | 1.37 [0.45-4.17] | 0.580 | - | - | - | - |
Parasite clearance | Â | Â | Â | Â | Â | Â | Â |
Day3 Parasitemia | 8,788 (252) | 2.17 [0.88-5.35] | 0.092 | - | - | - | - |
Region | Â | Â | Â | Â | Â | Â | Â |
Africa (reference)g | 8,624 (245) | 1 | - | - | - | - | - |
Asia | 434 (20) | 1.27 [1.83-3.55] | 0.700 | 7.39 [3.45-15.86] | <0.001 | 4.8% | 21.6% |
S. Americah | 37 (0) | - | - | - | - | Â | Â |