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Table 5 Poisson regression of risk factors for mortality among patients receiving ART

From: The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during long-term antiretroviral therapy in South Africa: a cohort study

 

Unadjusted IRR (95%CI)

P -value*

Adjusted IRR (95%CI)

P -value*

Age (for each year increase)

1.04 (1.02-1.06)

<0.001

1.04 (1.02-1.06)

<0.001

Gender

    

Female

1.0

<0.001

1.0

0.002

Male

1.69 (1.25-2.29)

 

1.79 (1.21-2.66)

 

WHO stage at baseline

    

1/2

1.00

<0.001

1.0

0.011

3/4

3.34 (1.93-5.78)

 

2.06 (1.12-3.78)

 

Baseline anaemia severity

    

None

1.0

0.025

  

Mild

1.10 (0.67-1.80)

   

Moderate

1.66 (1.09-2.53)

   

Severe

2.28 (1.08-4.85)

   

Baseline CD4 category (cells/μL)

    

≥150

1.0

0.011

  

100-149

1.05 (0.66-1.67)

   

50-99

1.20 (0.77-1.86)

   

<50

1.83 (1.22-2.75)

   

Baseline viral load (cells/mL)

    

<5.0

1.0

0.007

  

≥5.0

1.51 (1.12-2.05)

   

CD4 category (cells/μL) (updated)**

    

≥500

1.0

<0.001

1.0

<0.001

200-499

2.05 (1.11-3.78)

 

1.38 (0.71-2.68)

 

100-199

6.39 (3.44-11.88)

 

2.75 (1.28-5.89)

 

<100

27.98 (15.59-50.22)

 

6.50 (2.82-15.00)

 

Viral load (cells/mL) (updated)**

    

<1,000

1.0

<0.001

1.0

0.034

≥1,000

6.91 (5.18-9.22)

 

1.62 (1.04-2.53)

 

WHO anaemia severity (updated)**

    

None

1.0

<0.001

1.0

<0.001

Mild

3.19 (2.11-4.81)

 

2.42 (1.55-3.77)

 

Moderate

10.89 (7.57-15.64)

 

6.03 (3.93-9.24)

 

Severe

25.94 (13.90-48.40)

 

7.99 (3.89-16.44)

 

Duration of ART (months)**

    

<4

1.0

<0.001

1.0

0.843

4-12

0.35 (0.24-0.52)

 

1.30 (0.77-2.16)

 

12-24

0.15 (0.10-0.24)

 

1.07 (0.55-2.07)

 

24-36

0.13 (0.08-0.21)

 

0.96 (0.46-1.99)

 

36-48

0.13 (0.08-0.22)

 

1.07 (0.46-2.46)

 

48-60

0.09 (0.05-0.17)

 

0.83 (0.32-2.17)

 

>60

0.08 (0.04-0.17)

 

0.78 (0.27-2.23)

 

Current AZT use

    

No

1.0

<0.001

1.0

0.501

Yes

0.38 (0.27-0.54)

 

0.86 (0.56-1.33)

 

Prevalent TB

    

No

1.0

<0.001

1.0

0.024

Yes

1.72 (1.27-2.33)

 

1.50 (1.06-2.14)

 

Incident TB

    

No

1.0

<0.001

1.0

<0.001

Yes

1.85 (1.34-2.55)

 

2.23 (1.47-3.37)

 
  1. Abbreviations:ART antiretroviral, TB tuberculosis, WHO World Health Organization, IRR incident rate ratio.
  2. *P-values calculated using likelihood ratio tests.
  3. **No evidence for interaction between time-updated anaemia severity and time-updated CD4 count, time-updated viral load, duration of ART, WHO stage at ART initiation.