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Table 1 Numbers and class of drugs dispensed to adults in 1995 and 2010

From: The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010

 

1995

2010

2010

 

No. (%) of patients n = 301,019

No. (%) of patients n = 311,881

Age-sex standardised %*

Age-sex standardised relative risk 2010 vs. 1995 (95% CI)

Dispensed 0 drugs

148,828 (49.4)

128,155 (41.1)

42.8

0.87 (0.86–0.87)

Dispensed 1–4 drugs

117,829 (39.1)

114,540 (36.7)

36.4

0.93 (0.92–0.94)

Dispensed 5–9 drugs

29,311 (9.7)

50,972 (16.3)

15.3

1.57 (1.55–1.60)

Dispensed 10–14 drugs

4,481 (1.5)

14,662 (4.7)

4.4

2.92 (2.83–3.02)

Dispensed ≥15 drugs

570 (0.2)

3,552 (1.1)

1.1

5.58 (5.11–6.10)

Dispensed any drug from BNF chapter

    

1 (gastrointestinal)

37,813 (12.6)

56,536 (18.1)

17.1

1.36 (1.35–1.38)

2 (cardiovascular)

50,593 (16.8)

85,140 (27.3)

25.2

1.49 (1.48–1.51)

3 (respiratory)

18,368 (6.1)

24,760 (7.9)

7.7

1.26 (1.24–1.28)

4 (central nervous system)

55,920 (18.6)

81,902 (26.3)

25.4

1.37 (1.36–1.38)

5 (infections)

48,610 (16.1)

46,934 (15.0)

14.8

0.92 (0.90–0.93)

6 (endocrine)

26,469 (8.8)

44,695 (14.3)

13.5

1.53 (1.51–1.55)

7 (O&G, and urinary tract)

11,695 (3.9)

23,126 (7.4)

7.4

1.91 (1.87–1.95)

8 (malignancy, immunosuppression)

1,686 (0.6)

3,062 (1.0)

0.9

1.64 (1.54–1.74)

9 (nutrition and blood)

8,634 (2.9)

15,217 (4.9)

4.7

1.62 (1.58–1.67)

10 (musculoskeletal)

26,166 (8.7)

26,185 (8.4)

8.0

0.92 (0.91–0.94)

11 (eye)

8,166 (2.7)

11,726 (3.8)

3.5

1.30 (1.27–1.34)

12 (ear, nose, and throat)

8,633 (2.9)

12,459 (4.0)

3.8

1.34 (1.30–1.37)

13 (skin)

23,345 (7.8)

31,644 (10.1)

9.9

1.28 (1.26–1.30)

Number of BNF chapters dispensed drugs from

    

0

148,828 (49.4)

128,155 (41.1)

42.8

0.87 (0.86–0.87)

1

65,584 (21.8)

64,625 (20.7)

20.7

0.95 (0.94–0.96)

2

40,561 (13.5)

45,439 (14.6)

14.2

1.05 (1.04–1.07)

3

22,548 (7.5)

30,129 (9.7)

9.2

1.23 (1.21–1.25)

4

12,581 (4.2)

19,646 (6.3)

5.9

1.42 (1.39–1.45)

5+

10,917 (3.6)

23,887 (7.7)

7.1

1.97 (1.92–2.01)

  1. *2010 data directly age-sex standardised to 1995 population structure.