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Table 3 Sensitivity analyses excluding participants with thyroid medication or thyroid disease at baseline

From: Thyroid function and age-related macular degeneration: a prospective population-based cohort study - the Rotterdam Study

Incident AMD versus no AMD AMD N Total N HR (95% CI), model 1 HR (95% CI), model 2 HR (95% CI), model 3
Excluded thyroid medication      
Free T4 752 5,225 1.03 (1.01-1.06) 1.03 (1.01-1.06) 1.03 (1.01-1.06)
TSH, mIU/L 778 5,417 0.99 (0.91-1.08) 1.00 (0.92-1.09) 1.00 (0.91-1.09)
Excluding baseline thyroid diseaseb      
Free T4 751 5,237 1.04 (1.01-1.08) 1.04 (1.01-1.07) 1.04 (1.01-1.08)
TSH, mIU/L 764 5,300 0.98 (0.89-1.07) 0.98 (0.89-1.07) 0.97 (0.89-1.07)
  1. a155 participants had thyroid medication (thyroid hormone use) at baseline.
  2. b272 participants had self-reported thyroid disease at baseline.
  3. Model 1: Adjusted for sex and age. Model 2: Model 1 + smoking, hypertension, cholesterol, diabetes, BMI. Model 3: Model 2 + thyroid peroxidase antibodies positivity.
  4. Abbreviations: BMI body mass index, CI confidence interval, FT4 free thyroxine, HR hazard ratio, TSH thyroid-stimulating hormone.