A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder

Table 2 Linear regression models with BMI as the outcome variable

Study/sample	Model	F	Adj. R ²	Additional variance explained by GRS
*Radiant*
Total	Model 1: adjusted by age, sex, and depression	38.98	0.0829	1.27%
Total	Model 2: model 1 + wGRS	39.16	0.0956	1.27%
Depressed cases	Model 1: adjusted by age and sex	17.85	0.0426	1.63%
Depressed cases	Model 2: model 1 + wGRS	20.75	0.0589	1.63%
Controls	Model 1: adjusted by age and sex	11.71	0.0789	0.34%
Controls	Model 2: model 1 + wGRS	10.34	0.0823	0.34%
*GSK-Munich*
Total	Model 1: adjusted by age, sex, and depression	34.02	0.1056	0.53%
Total	Model 2: model 1 + wGRS	29.80	0.1109	0.53%
Depressed cases	Model 1: adjusted by age and sex	8.02	0.0372	1.32%
Depressed cases	Model 2: model 1 + wGRS	7.13	0.0504	1.32%
Controls	Model 1: adjusted by age and sex	25.66	0.1306	0.23%
Controls	Model 2: model 1 + wGRS	21.98	0.1329	0.23%
*PsyCoLaus*
Total	Model 1: adjusted by age, sex, and depression	40.20	0.0843	0.93%
Total	Model 2: model 1 + wGRS	39.47	0.0936	0.93%
Depressed cases	Model 1: adjusted by age and sex	14.84	0.0605	1.09%
Depressed cases	Model 2: model 1 + wGRS	15.15	0.0714	1.09%
Controls	Model 1: adjusted by age and sex	31.25	0.0970	0.77%
Controls	Model 2: model 1 + wGRS	29.21	0.1047	0.77%

ISSN: 1741-7015