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Table 3 Accuracy characteristics of microRNAs in discriminating metastatic and non-metastatic lymph nodes in FFPE and FNA biopsies from lymph node samples

From: Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma

microRNA PPV NPV Accuracy AUC (95% CI)
% (95% CI) % (95% CI) % (95% CI)
FFPE samples
miR-200a 100 (82.2–100.0) 68.4 (43.5–87.3) 84.2 (68.1–93.4) 0.92 (0.83–0.99)
miR-200c 100 (84.4–100.0) 81.2 (54.34–95.73) 92.1 (77.5–97.9) 0.94 (0.85–1.0)
miR-203 100 (86.2–100) 100 (75.1–100) 100 (88.6–100) 1.0 (0–1.0)
miR-205 100 (86.2–100) 100 (75.1–100) 100 (88.6–100) 1.0 (0–1.0)
FNA samples classified by cytology
miR-203 100 (91.5–100) 100 (94.9–100) 100 (96.05–100) 1.0 (0–1.0)
miR-205 100 (91.5–100) 100 (94.9–100) 100 (96.05–100) 1.0 (0–1.0)
FNA samples classified by histology
miR-203 100 (90.9–100) 95.9 (88.6–99.1) 97.3 (92.1–99.4) 0.963 (0.921–1.0)
miR-205 100 (93.2–100) 94.6 (85.1–98.8) 96.7 (93.1–100) 0.966 (0.921–1.0)
  1. FFPE, Formalin-fixed paraffin embedded; FNA, Fine-needle aspiration; PPV, Positive predictive value; NPV, Negative predictive value; AUC, Area under the ROC curve; CI, Confidence interval.