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Table 3 Statistically significant results of network meta-analysis for all time periods of drug administration

From: Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

  All ages Children only
Treatment comparison Number of studies MA estimate: OR (95 % CI) NMA estimate: OR (95 % CI) Number of studies MA estimate: OR (95 % CI) NMA estimate: OR (95 % CI)
Arrhythmia 31 RCTs and 6,623 patients 9 RCTs and 1,572 patients
Granisetron + DEX vs placebo 2 2.63 (0.75– 9.29) 2.96 (1.11–7.94) 1 4.89 (1.15–20.79) 5.15 (1.33–19.91)
Granisetron + DEX vs ondansetron NA NA 3.23 (1.17–8.95) NA NA 4.71 (1.08–20.46)
Granisetron + DEX vs dolasetron NA NA 4.37 (1.51–12.62) NA NA NA
Granisetron + DEX vs tropisetron NA NA 3.27 (1.02–10.43) NA NA NA
Granisetron + DEX vs ondansetron + DEX 2 8.10 (1.92–34.13) 5.75 (1.71–19.34) 1 7.67 (1.47–40.00) 7.12 (1.66–30.63)
  1. CI: Confidence interval; DEX: Dexamethasone; MA: Meta-analysis; NA: Not applicable; NMA: Network meta-analysis; OR: Odds ratio