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Table 8 Comparing rates of tuberculosis in 198,227 patients with type 2 diabetes (T2DM) and HbA1c measurements with a matched unexposed cohort

From: Risk of tuberculosis in patients with diabetes: population based cohort study using the UK Clinical Practice Research Datalink

    Age adjusted   Fully adjusted modela  
Exposure group Number of patients TB cases/PYb Ratec (95 % CI) Rate ratio Rate ratio P-value*
(% of T2DM) (95 % CI) (95 % CI)
Patients without diabetes 1,088,376 689/50.97 13.51 (12.54–14.56) 1.00 1.00  
Patients with T2DM       
HbA1c mmol/mol (%):       
≤48 (6.5) 61,336 (30.9) 50/2.86 17.48 (13.25–23.06) 1.29 (0.97–1.72) 1.34 (0.88–2.05) 0.140
49- ≤ 58 (6.5–7.5) 70,470 (35.6) 54/3.98 13.57 (10.39–17.72) 1.00 (0.76–1.32) 1.14 (0.76–1.70)  
>58 (>7.5) 66,421 (33.5) 71/3.99 17.81 (14.12–22.48) 1.32 (1.03–1.68) 1.50 (1.04–2.17)  
  1. *P-value from likelihood ratio test
  2. aModel adjusted for: age, BMI, smoking status, alcohol status, ethnicity and IMD
  3. bPY: 100,000 person years at risk
  4. cRate: per 100,000 person years
  5. BMI body mass index, CI confidence interval, IMD index of multiple deprivation, TB tuberculosis