Table 2 Pathway analysis of genes with CpG sites differentially methylated in cases with PDR versus controls
KEGG pathway: Natural Killer cell mediated cytotoxicity (P = 0.0001; Padj = 0.0063) | ||
|---|---|---|
Total # of genes in pathway: 121 | Expected # of genes: 1.48 | Observed # of genes: 8 |
Gene symbol | Description | |
KLRD1 | Killer cell lectin-like receptor subfamily D, member 1 | |
TNF | Tumor necrosis factor | |
CD247 | CD247 molecule | |
PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | |
GZMB | Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | |
NFATC1 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | |
PRF1 | Perforin 1 (pore forming protein) | |
KIR2DL4 | Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | |