Skip to main content

Table 2 Pathway analysis of genes with CpG sites differentially methylated in cases with PDR versus controls

From: Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy

KEGG pathway: Natural Killer cell mediated cytotoxicity (P = 0.0001; Padj = 0.0063)
Total # of genes in pathway: 121 Expected # of genes: 1.48 Observed # of genes: 8
Gene symbol Description
KLRD1 Killer cell lectin-like receptor subfamily D, member 1
TNF Tumor necrosis factor
CD247 CD247 molecule
PIK3CD Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
GZMB Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
NFATC1 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
PRF1 Perforin 1 (pore forming protein)
KIR2DL4 Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4