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Table 1 Systemic adjuvant therapy options for operable breast cancer

From: Progress in adjuvant chemotherapy for breast cancer: an overview

Breast cancer subtype/classification Adjuvant systemic therapy
Phenotypic subtype Intrinsic subtype Endocrine therapy Anti-HER2 therapy Chemotherapy
Hormone receptors HER2 overexpression     
+ Luminal A or B Yes No Yes (if high risk)
+ + Luminal B or HER2 enriched Yes Yes Yes
Basal No No Yes
+ HER2 enriched No Yes Yes