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Table 1 Serum conversion rates in children immunized with the EV71 vaccine who provided a full series of blood samples within the 2-year follow-up perioda

From: Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations

Age group (Months)

Days post immunization

Vaccineb

Placebob

P value

6–11

0

0/48 (0.0)

1/50 (2.0)

1.000

 

56

48/48 (100.0)

1/50 (2.0)

<0.0001

 

180

47/48 (97.9)

8/50 (16.0)

<0.0001

 

360

47/48 (97.9)

9/50 (18.0)

<0.0001

 

540

47/48 (97.9)

14/50 (28.0)

<0.0001

 

720

48/48 (100.0)

15/50 (30.0)

<0.0001

12–23

0

2/50 (4.0)

2/63 (3.2)

1.000

 

56

50/50 (100.0)

2/63 (3.2)

<0.0001

 

180

50/50 (100.0)

18/63 (28.6)

<0.0001

 

360

50/50 (100.0)

19/63 (30.2)

<0.0001

 

540

50/50 (100.0)

22/63 (34.9)

<0.0001

 

720

48/50 (96.0)

27/63 (42.9)

<0.0001

24–35

0

5/43 (11.6)

12/52 (23.1)

0.184

 

56

43/43 (100.0)

12/52 (23.1)

<0.0001

 

180

43/43(100.0)

29/52 (55.8)

<0.0001

 

360

42/43 (97.4)

31/52 (59.6)

<0.0001

 

540

43/43 (100.0)

31/52 (59.6)

<0.0001

 

720

43/43 (100.0)

35/52 (67.3)

<0.0001

36–71

0

5/20 (25.0)

13/24 (54.2)

0.047

 

56

20/20 (100.0)

13/24 (54.2)

<0.0001

 

180

20/20 (100.0)

19/24 (79.2)

0.031

 

360

20/20 (100.0)

19/24 (79.2)

0.031

 

540

20/20 (100.0)

18/24 (75.0)

0.016

 

720

19/20 (95.0)

18/24 (75.0)

0.071

Total

0

12/161 (7.5)

28/189 (14.8)

0.028

 

56

161/161 (100.0)

28/189 (14.8)

<0.0001

 

180

160/161 (99.4)

74/189 (39.2)

<0.0001

 

360

159/161 (98.8)

78/189 (41.3)

<0.0001

 

540

160/161 (99.4)

85/189 (45.0)

<0.0001

 

720

158/161 (98.1)

95/189 (50.3)

<0.0001

  1. aNeutralization antibody titre ≥1:8.
  2. bPositive rate – Number (%)