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Table 2 Baseline characteristics

From: A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease

 

All participants

Participants lost

Remaining participants

Variable

Three sessions

Single session

Total

Three

Single

Three

Single

N

52

104

156

9

23

43

81

Withdrew at baseline

2

2

4

    

Age in years:

       

mean (SD [MS]

68 (11) [0]

69 (9) [1]

69 (9) [1]

67 (8) [0]

68 (8) [1]

69 (11) [0]

70 (9) [0]

min, max

38, 87

47, 92

38, 92

53, 77

55, 83

38, 87

47, 92

Sex: N (%) [MS]

       

Female

21 (43) [1]

39 (39) [2]

60 (40) [3]

1 (11) [0]

6 (29) [2]

21 (50) [1]

33 (41) [0]

Intrathoracic tumour: N (%)

[0 MS]

[2 MS]

[2 MS]

[0 MS]

[2 MS]

[0 MS]

[0 MS]

Non-small cell

14 (28)

21 (21)

35 (23.3)

4 (44)

5 (24)

11 (26)

17 (21)

Small cell

1 (2)

4 (4)

5 (3.3)

 

2 (9)

1 (2)

2 (2)

Lung (histology not stated)

30 (60)

63 (63)

93 (62)

5(56)

13 (62)

26 (60)

51 (63)

Mesothelioma

4 (8)

8 (8)

12 (8)

 

1 (5)

4 (9)

7 (9)

Other

1 (2)

4 (4)

5 (3.3)

  

1 (2)

4 (5)

Metastases: N (%) [MS]

       

Yes

9 (19) [2]

14 (16) [12]

23 (17) [14]

1 (14) [2]

5 (29) [6]

8 (19) [1]

9 (12) [6]

Preference: N (%)

[0 MS]

[1 MS]

[1 MS]

[0 MS]

[1 MS]

[0 MS]

[0 MS]

High

14 (28)

20 (20)

34 (22.5)

1 (11)

3 (14)

13 (30)

17 (21)

Low

8 (16)

26 (26)

34 (22.5)

3 (33)

5 (23)

6 (14)

22 (27)

No preference

28 (56)

55 (54)

83 (55)

5 (56)

14 (64)

24 (56)

42 (52)

Smoking: N (%)

[0 MS]

[2 MS]

[2 MS]

[1 MS]

[1 MS]

[0 MS]

[1 MS]

Never

6 (12)

7 (7)

13 (9)

  

6 (14)

7 (9)

Current

7 (14)

16 (16)

23 (15)

2 (25)

3 (14)

5 (12)

13 (16)

Ex-smoker

37 (74)

77 (77)

114 (76)

6 (75)

19 (86)

32 (74)

60 (75)

Karnofsky

       

Mean (SD) [MS]

70.6 (9.0) [3]

70.6 (9.9) [7]

70.6 (9.5) [10]

62.5 (8.9) [1]

63.8 (13.2) [2]

71.7 (8.6) [2]

72.2 (7.9) [5]

Breathlessness scores NRS: mean (SD) [MS]

       

Worst

6.7 (2.0) [6]

6.9 (1.9) [12]

6.8 (1.9) [18]

7.6 (1.8) [1]

7.4 (1.8) [3]

6.6 (2.0) [6]

6.7 (1.9) [10]

Average

5.4 (1.8) [6]

5.6 (1.6) [13]

5.5 (1.7) [19]

6.0 (1.3) [1]

6.6 (2.0) [3]

5.3 (1.9) [6]

5.3 (1.4) [11]

Distress

4.7 (2.8) [7]

4.6 (3.1) [12]

4.6 (3.0) [19]

4.5 (2.3) [1]

5.7 (3.0) [3]

4.7 (2.8) [7]

4.3 (3.1) [10]

Cope

6.4 (2.1) [6]

7.0 (2.1) [12]

6.8 (2.1) [18]

6.3 (2.4) [1]

6.3 (2.1) [3]

6.5 (2.0) [6]

7.2 (2.1) [10]

Care provided

6.3 (3.4) [9]

6.5 (3.4) [20]

6.5 (3.4) [29]

5.6 (2.8) [2]

6.0 (3.6) [4]

6.3 (3.6) [8]

6.8 (3.3) [17]

Chronic Respiratory Questionnaire – SAS: mean (SD) [MS]

       

Dyspnoea domain

4.41 (1.25) [0]

4.38 (1.31) [1]

4.39 (1.30) [1]

3.95 (1.32) [1]

4.38 (1.43) [1]

4.50 (1.22) [0]

4.38 (1.27) [0]

Fatigue

3.02 (0.95) [0]

3.32 (1.11) [2]

3.22 (1.07) [2]

2.72 (0.81) [1]

2.94 (1.14) [2]

3.06 (0.97) [0]

3.41 (1.08) [0]

Emotional function

4.17 (1.10) [0]

4.50 (1.28) [2]

4.39 (1.23) [2]

3.54 (1.12) [1]

3.81 (1.38) [2]

4.26 (1.09) [0]

4.68 (1.17) [0]

Mastery

3.90 (1.19) [0]

4.48 (1.17) [2]

4.2 9 (1.20) [2]

2.94 (0.50) [1]

3.78 (1.35) [2]

4.06 (1.19) [0]

4.66 (1.03) [0]

Hospital Anxiety and Depression Scale (HADS): mean (SD) [MS]

       

Anxiety

7.6 (4.3) [0]

6.1 (4.4) [4]

6.6 (4.3) [4]

8.5 (4.8) [1]

8.4 (5.0) [3]

7.6 (4.3) [0]

5.6 (3.7) [1]

Depression

6.6 (3.0) [0]

6.2 (3.9) [2]

6.3 (3.6) [2]

8.1 (2.2) [1]

7.9 (4.9) [2]

6.4 (3.1) [0]

5.8 (3.5) [0]

Big Five Inventory (BFI): [MS] mean (SD)

[0]

[4]

[4]

[1]

[4]

[0]

[1]

Extraversion

3.06 (0.75)

3.30 (0.83)

3.22 (0.81)

3.11 (0.94)

3.00 (0.78)

3.05 (0.71)

3.37 (0.82)

Agreeableness

4.22 (0.53)

4.16 (0.64)

4.18 (0.60)

3.96 (0.65)

3.99 (0.91)

4.26 (0.49)

4.20 (0.55)

Conscientiousness

4.00 (0.64)

4.11 (0.61)

4.07 (0.62)

3.90 (0.60)

3.94 (0.69)

4.00 (0.66)

4.16 (0.59)

Neuroticism

2.64 (0.83)

2.51 (0.88)

2.55 (0.86)

3.01 (0.89)

2.93 (1.08)

2.60 (0.82)

2.40 (0.80)

Openness

3.32 (0.75)

3.30 (0.70)

3.31 (0.71)

3.09 (0.81)

3.11 (0.81)

3.34 (0.75)

3.34 (0.67)

Mental Toughness Questionnaire (MTQ48): [MS] mean (SD)

[1]

[4]

[5]

[3]

[5]

[0]

[0]

Challenge

3.7 (0.7)

3.8 (0.7)

3.78 (0.7)

3.7 (0.7)

3.7 (0.8)

3.7 (0.7)

3.8 (0.6)

Commitment

3.6 (0.7)

3.8 (0.6)

3.7 (0.6)

3.5 (0.7)

3.5 (0.8)

3.6 (0.7)

3.8 (0.6)

Control emotion

3.3 (0.6)

3.3 (0.6)

3.3 (0.6)

3.3 (0.4)

3.1 (0.8)

3.25 (0.7)

3.3 (0.6)

Control life

3.6 (0.7)

3.7 (0.7)

3.7 (0.7)

3.7 (0.9)

3.5 (0.8)

3.59 (0.7)

3.77 (0.6)

Confidence abilities

3.6 (0.6)

3.7 (0.6)

3.7 (0.6)

3.7 (0.5)

3.5 (0.8)

3.6 (0.6)

3.68 (0.6)

Confidence interpersonal

3.72 (0.82)

3.84 (0.75)

3.80 (0.77)

4.12 (0.99)

3.83 (0.66)

3.67 (0.79)

3.83 (0.78)

Pre-randomisation patient stated preference for study allocation: [MS] N (%)

[0]

[1]

[1]

[0]

[1]

[0]

[0]

Three sessions

14 (28)

20 (20)

34 (22.5)

1 (11)

3 (14)

13 (30)

17 (21)

Single session

8 (16)

26 (26)

34 (22.5)

3 (33)

5 (23)

6 (14)

22 (27)

No preference

28 (56)

55 (54)

83 (55)

5 (56)

14 (64)

24 (56)

42 (52)

  1. **Adjusted for baseline breathlessness intensity, gender, smoking status, and age; Descriptive statistics of the primary and secondary breathlessness outcome measures, P values and unadjusted and adjusted confidence intervals for the difference between the two arms
  2. N = number SAS, Self-administered survey (supported by research nurse); SD, Standard deviation; AUC, Area under the curve. MS = Missing