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Table 3 Primary analysis point (4 weeks)

From: A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease

Variable Three sessions One session Total P-Value 95% Confidence Interval Adjusted coefficient ** (95% Confidence Interval)
N with sufficient NRS scores over 4 weeks to calculate AUC 43 81 124    
AUC (Cubic) by Week 4 Breathlessness NRS: mean (SD)       
Worst 22•86(7•12) 22•58(7•10) 22•68(7•08) 0•83 (-2•31, 2•87) 1•05 (-1•64,3•75)
Average 19•45(6•51) 19•14(6•27) 19•24(6•33) 0•79 (-2•00, 2•62) 0•81 (-1•48,3•10)
Distress* (NHI =42, NLI = 84) 16•23(7•17) 12•29(8•27) 13•60(8•11) 0•01 (0•98,6•91) 3•24 (0•25,6•23)
Cope 25•47(7.36) 27.16(6.96) 26.58(7.12) 0.20 (-4.27, 0.90) −0.87 (-3.72,1.99)
Care 31.02(8.62) 31.11(8.13) 31.08(8.27) 0.95 (-3.11,2.93) 0.25 (-2.78,3.28)
Chronic Respiratory Questionnaire -SAS at Week 4: mean (SD) N= 37 N= 71 N = 108    
Dyspnoea domain 4•41(1•33) 4•62(1•43) 4•55(1•39) 0•47 (-0•77,0•35) −0•38 (-0•89,0•13)
Fatigue 3•36(1•05) 3•47(1•25) 3•43(1•18) 0•63 (-0•59,0•36) 0•06 (-0•40,0•51)
Emotional Function 4•59(1•08) 4•68(1•13) 4•65(1•11) 0•69 (-0•54,0•36) 0•12 (-0•26,0•51)
Mastery 4•44(1•25) 5•03(1•15) 4•83(1•21) 0•02 (-1•06,-0•11) −0•34 (-0•75,0•07)
  1. Descriptive statistics of the primary and secondary breathlessness outcome measures, P-values and unadjusted and adjusted confidence intervals for the difference between the two arms
  2. SAS self administered survey (supported by research nurse); SD standard deviation; AUC area under the curve; NHI number in three sessions arm; NLI number in one-session arm
  3. *adjusted for baseline breathlessness intensity, gender, smoking status and age
  4. P-values based on student’s test with equal variance assumed