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Table 3 Primary analysis point (4 weeks)

From: A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease

Variable

Three sessions

One session

Total

P-Value†

95% Confidence Interval

Adjusted coefficient ** (95% Confidence Interval)

N with sufficient NRS scores over 4 weeks to calculate AUC

43

81

124

   

AUC (Cubic) by Week 4 Breathlessness NRS: mean (SD)

      

Worst

22•86(7•12)

22•58(7•10)

22•68(7•08)

0•83

(-2•31, 2•87)

1•05 (-1•64,3•75)

Average

19•45(6•51)

19•14(6•27)

19•24(6•33)

0•79

(-2•00, 2•62)

0•81 (-1•48,3•10)

Distress* (NHI =42, NLI = 84)

16•23(7•17)

12•29(8•27)

13•60(8•11)

0•01

(0•98,6•91)

3•24 (0•25,6•23)

Cope

25•47(7.36)

27.16(6.96)

26.58(7.12)

0.20

(-4.27, 0.90)

−0.87 (-3.72,1.99)

Care

31.02(8.62)

31.11(8.13)

31.08(8.27)

0.95

(-3.11,2.93)

0.25 (-2.78,3.28)

Chronic Respiratory Questionnaire -SAS at Week 4: mean (SD)

N= 37

N= 71

N = 108

   

Dyspnoea domain

4•41(1•33)

4•62(1•43)

4•55(1•39)

0•47

(-0•77,0•35)

−0•38 (-0•89,0•13)

Fatigue

3•36(1•05)

3•47(1•25)

3•43(1•18)

0•63

(-0•59,0•36)

0•06 (-0•40,0•51)

Emotional Function

4•59(1•08)

4•68(1•13)

4•65(1•11)

0•69

(-0•54,0•36)

0•12 (-0•26,0•51)

Mastery

4•44(1•25)

5•03(1•15)

4•83(1•21)

0•02

(-1•06,-0•11)

−0•34 (-0•75,0•07)

  1. Descriptive statistics of the primary and secondary breathlessness outcome measures, P-values and unadjusted and adjusted confidence intervals for the difference between the two arms
  2. SAS self administered survey (supported by research nurse); SD standard deviation; AUC area under the curve; NHI number in three sessions arm; NLI number in one-session arm
  3. *adjusted for baseline breathlessness intensity, gender, smoking status and age
  4. †P-values based on student’s test with equal variance assumed