Skip to main content

Table 2 P values, q values, and fold differences of metabolites observed to be statistically significantly different between HCC cases (n = 114) and matched controls (n = 222)

From: Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

 

HCC cases vs. matched controls

Metabolites

P valuea

q valueb

Fold difference

Lipids = CH-CH2-CH=

9 × 10-11

3 × 10-08

0.84

N-acetyl glycoproteins

3 × 10-10

4 × 10-08

0.90

Unspecificc,d

4 × 10-10

4 × 10-08

0.82

Glutamate

4 × 10-09

3 × 10-07

1.22

Tyrosine

1 × 10-08

7 × 10-07

1.24

Choline

2 × 10-08

7 × 10-07

0.82

Lipids O-CH2

1 × 10-07

3 × 10-06

0.84

Phenylalanine

2 × 10-07

5 × 10-06

1.23

Unspecificc,e

4 × 10-07

9 × 10-06

0.84

Leucine

2 × 10-06

3 × 10-05

0.91

Lipids CH2-CH2-COOC

2 × 10-06

3 × 10-05

0.82

Unsaturated lipidsf

2 × 10-06

3 × 10-05

0.86

Isoleucine

2 × 10-05

2 × 10-04

0.90

Lipids CH2-CH=

2 × 10-05

2 × 10-04

0.94

CH3 bond of lipids (VLDL)g

2 × 10-05

2 × 10-04

0.87

Propylene glycol

7 × 10-05

6 × 10-04

1.45

Lipids (CH2)n

1 × 10-04

8 × 10-04

0.88

Ethanol

3 × 10-04

2 × 10-03

1.65

Glutamine

7 × 10-04

4 × 10-03

0.90

Glucose

8 × 10-04

4 × 10-03

1.10

Valine

3 × 10-03

1 × 10-02

0.93

Acetate

5 × 10-03

2 × 10-02

1.24

Citrate

1 × 10-02

4 × 10-02

1.08

  1. aP value was obtained from ANOVA mixed-effects models
  2. bq value corresponds to the value obtained after Benjamini-Hochberg correction for multiple testing
  3. cMultiple assignments for the same cluster of variables due to spectral overlap
  4. dAcetone and CH2-CH2-COOC of bound lipids
  5. eMannose and glyceride of lipids
  6. fUnsaturated lipids as estimated from the CH = CH signal of lipids
  7. gPart of terminal lipids methyl signal corresponding to VLDLs