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Table 2 P values, q values, and fold differences of metabolites observed to be statistically significantly different between HCC cases (n = 114) and matched controls (n = 222)

From: Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

  HCC cases vs. matched controls
Metabolites P valuea q valueb Fold difference
Lipids = CH-CH2-CH= 9 × 10-11 3 × 10-08 0.84
N-acetyl glycoproteins 3 × 10-10 4 × 10-08 0.90
Unspecificc,d 4 × 10-10 4 × 10-08 0.82
Glutamate 4 × 10-09 3 × 10-07 1.22
Tyrosine 1 × 10-08 7 × 10-07 1.24
Choline 2 × 10-08 7 × 10-07 0.82
Lipids O-CH2 1 × 10-07 3 × 10-06 0.84
Phenylalanine 2 × 10-07 5 × 10-06 1.23
Unspecificc,e 4 × 10-07 9 × 10-06 0.84
Leucine 2 × 10-06 3 × 10-05 0.91
Lipids CH2-CH2-COOC 2 × 10-06 3 × 10-05 0.82
Unsaturated lipidsf 2 × 10-06 3 × 10-05 0.86
Isoleucine 2 × 10-05 2 × 10-04 0.90
Lipids CH2-CH= 2 × 10-05 2 × 10-04 0.94
CH3 bond of lipids (VLDL)g 2 × 10-05 2 × 10-04 0.87
Propylene glycol 7 × 10-05 6 × 10-04 1.45
Lipids (CH2)n 1 × 10-04 8 × 10-04 0.88
Ethanol 3 × 10-04 2 × 10-03 1.65
Glutamine 7 × 10-04 4 × 10-03 0.90
Glucose 8 × 10-04 4 × 10-03 1.10
Valine 3 × 10-03 1 × 10-02 0.93
Acetate 5 × 10-03 2 × 10-02 1.24
Citrate 1 × 10-02 4 × 10-02 1.08
  1. aP value was obtained from ANOVA mixed-effects models
  2. bq value corresponds to the value obtained after Benjamini-Hochberg correction for multiple testing
  3. cMultiple assignments for the same cluster of variables due to spectral overlap
  4. dAcetone and CH2-CH2-COOC of bound lipids
  5. eMannose and glyceride of lipids
  6. fUnsaturated lipids as estimated from the CH = CH signal of lipids
  7. gPart of terminal lipids methyl signal corresponding to VLDLs