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Table 3 Relationship between immunohistochemistry-based subgroups and PAM50-based intrinsic subtypes

From: Molecular essence and endocrine responsiveness of estrogen receptor-negative, progesterone receptor-positive, and HER2-negative breast cancer

   Gene-expression based subtype (by PAM50 classifier)
IHC-based subgroup (HER2–) Total (n) Luminal-A (n) % Luminal-B (n) % Basal (n) % HER2+ (n) % Normal-like (n) % P
Cohort 3             <0.001
 ER+/PgR+ 391 179 45.8 168 43.0 20 5.1 7 1.8 17 4.3  
 ER−/PgR+ 36 6 16.7 6 16.7 20 55.6 3 8.3 1 2.8  
 ER−/PgR− 280 9 3.2 27 9.6 207 73.9 25 8.9 12 4.3  
Cohort 4             <0.001
 ER+/PgR+ 216 126 58.3 50 23.1 13 6.0 12 5.6 15 6.9  
 ER−/PgR+ 17 3 17.6 1 5.9 11 64.7 1 5.9 1 5.9  
 ER−/PgR− 178 2 1.1 3 1.7 142 79.8 14 7.9 17 9.6  
  1. IHC Immunohistochemistry