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Table 3 Analysis of neutropenia across all treatments (classification National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) grade ≥1 vs. grade 0)

From: A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

Toxicity n (univariable analysis) n (multivariable analysis) BCSS RFS
Unadjusted Adjusted Unadjusted Adjusted
HR (95 % CI) P value HR (95 % CI) P value HR (95 % CI) P value HR (95 % CI) P value
Neutropenia 5,886 5,211 0.86 (0.77–0.96) 0.009 0.87 (0.77–0.99) 0.03 0.91 (0.83–0.99) 0.04 0.91 (0.82–1.01) 0.07
  1. BCSS Breast cancer-specific survival; RFS Relapse-free survival; HR Hazard ratio; CI, Confidence interval